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1. (WO1999011808) RNA RESPIRATORY SYNCYTIAL VIRUS VACCINES

Pub. No.:    WO/1999/011808    International Application No.:    PCT/CA1998/000840
Publication Date: Mar 11, 1999 International Filing Date: Sep 3, 1998
IPC: C07K 14/115
C07K 14/135
C12N 15/86
Applicants: CONNAUGHT LABORATORIES LIMITED
PARRINGTON, Mark
Inventors: PARRINGTON, Mark
Title: RNA RESPIRATORY SYNCYTIAL VIRUS VACCINES
Abstract:
A vector comprising a first DNA sequence which is complementary to at least part of an alphavirus RNA genome and having the complement of complete alphavirus DNA genome replication regions, a second DNA sequence encoding a paramyxovirus protein, particularly a respiratory syncytial virus fusion (RSV F) protein or an RSV F protein fragment that generates antibodies that specifically react with RSV F protein, the first and second DNA sequences being under the transcriptional control of a promoter is described. Such vector may be used to produce an RNA transcript which may be used to immunize a host, including a human host, to protect the host aginst disease caused by paramyxovirus, particularly respiratory syncytial virus, by administration to the host. The RNA transcript may be formed by linearization of the vector through cleavage at a unique restriction site in a plasmid vector and then transcribing the linear molecule.