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1. (WO1999011630) SUBSTITUTED TETRAHYDRO-PYRIMIDINE-2(1H)-THIONE HDL-C ELEVATORS USEFUL AS ANTIATHEROSCLEROTIC AGENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1999/011630    International Application No.:    PCT/US1998/017958
Publication Date: 11.03.1999 International Filing Date: 31.08.1998
Chapter 2 Demand Filed:    15.02.1999    
IPC:
C07D 239/10 (2006.01)
Applicants: AMERICAN HOME PRODUCTS CORPORATION [US/US]; Five Giralda Farms Madison, NJ 07940-0874 (US)
Inventors: FAILLI, Amedeo, Arturo; (US).
SHUMSKY, Jay, Scott; (US).
MEMOLI, Kevin, Anthony; (US).
STRIKE, Donald, Peter; (US)
Agent: ALICE, Ronald, W.; American Home Products Corporation Patent Law Dept. -2B One Campus Drive Parsippany, NJ 07054 (US).
WILEMAN, David, Francis; Wyeth Laboratories Huntercombe Lane South Taplow Maidenhead Berks SL6 0PH (GB)
Priority Data:
08/922,934 03.09.1997 US
Title (EN) SUBSTITUTED TETRAHYDRO-PYRIMIDINE-2(1H)-THIONE HDL-C ELEVATORS USEFUL AS ANTIATHEROSCLEROTIC AGENTS
(FR) TETRAHYDRO-PYRIMIDINE-2(1H)-THIONE SUBSTITUES ELEVATEURS DU HDL-C S'AVERANT UTILES COMME AGENTS ANTIATHEROSCLEREUX
Abstract: front page image
(EN)Compounds are provided having structure (1) wherein R?1¿ is hydrogen, alkyl of 1-6 carbon atoms, cycloalkyl of 3-8 carbon atoms, alkenyl of 2-7 carbon atoms, alkynyl of 2-7 carbon atoms, or phenylaklyl of 7-10 carbon atoms; and R?2¿, R?3¿, R?4¿, R?5¿ and R?6¿ are each, independently, hydrogen, halogen, alkyl of 1-6 carbon atoms, cycloalkyl of 3-8 carbon atoms, alkenyl of 2-7 carbon atoms, alkynyl of 2-7 carbon atoms, aralkyl of 7-10 carbon atoms, alkoxy of 1-6 carbon atoms, aryloxy of 6-12 carbon atoms, aralkyloxy of 7-12 carbon atoms, fluoroalkoxy of 1-6 carbon atoms, trifluoromethyl, alkylthio of 1-3 carbon atoms, alkylsulfonyl of 1-3 carbon atoms, -SCF¿3?, nitro, alkylamino in which the alkylamino moiety has 1-6 carbon atoms, or dialkylamino in which each alkyl group has 1-6 carbon atoms; or a pharmaceutically acceptable salt thereof to make a medicament for the treatment of cardiovascular disease.
(FR)L'invention porte sur des composés de structure (1) dans laquelle: R?1¿ est hydrogène, alkyle à 1 à 6 atomes de carbone, cycloalkyle à 3 à 8 atomes de carbone, alcényle à 2 à 7 atomes de carbone, alcynyle à 2 à 7 atomes de carbone, ou phénylalkyle à 7 à 10 atomes de carbone, R?2¿, R?3¿, R?4¿, R?5¿ et R?6¿ sont chacun indépendamment hydrogène, halogène, alkyle à 1 à 6 atomes de carbone, cycloalkyle à 3 à 8 atomes de carbone, alcényle à 2 à 7 atomes de carbone, alcynyle à 2 à 7 atomes de carbone, aralkyle à 7 à 10 atomes de carbone, alkoxy à 1 à 6 atomes de carbone, aryloxy à 6 à 12 atomes de carbone, trifluorométhyle, alkylthio à 1 à 3 atomes de carbone, alkylsulfonyle à 1 à 3 atomes de carbone, -SCF¿3?, nitro, alkylamino dans lequel le fragment alkylamino présente 1 à 6 atomes de carbone, ou dialkylamino dans lequel chacun des groupes alkyle présente 1 à 6 atomes de carbone; ou l'un de leurs sels pharmacocompatibles; constituant un médicament pour le traitement des maladies cardio-vasculaires.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, HR, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)