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1. (WO1999011607) METHOD FOR PRODUCING A 1-(3-CYCLOPENTENYLOXY- 4-ALKOXYPHENYL)-4- OXOCYCLOHEXANECARBONITRILE

Pub. No.:    WO/1999/011607    International Application No.:    PCT/EP1998/005504
Publication Date: Mar 11, 1999 International Filing Date: Aug 26, 1998
IPC: C07C 41/22
C07C 41/26
C07C 45/71
C07C 253/14
C07C 253/30
C07C 255/41
C07C 255/46
Applicants: LONZA AG
METTLER, Hans-Peter
Inventors: METTLER, Hans-Peter
Title: METHOD FOR PRODUCING A 1-(3-CYCLOPENTENYLOXY- 4-ALKOXYPHENYL)-4- OXOCYCLOHEXANECARBONITRILE
Abstract:
Disclosed is a novel method for producing 1-(3-cyclopentenyloxy- 4- alkoxyphenyl)-4- oxocyclohexanecarbonitrile of general formula (I). A 4-cyano-4- (3-cyclopentenyloxy- 4-methoxyphenyl)- heptanediaciddialkyl ester of general formula (II) is cyclized in the presence of a base to form a 5-cyano-5- (3-cyclopentyloxy-4- alkoxyphenyl)-2- oxocyclohexane carbonic acid ester of general formula (III), then the compound of general formula (III) is neutralized with an alkali metal hydrogen carbonate and finally decarboxylated in the presence of an alkali metal carbonate to form an end product according to formula (I).