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Machine translation
1. (WO1999010486) MDM2-SPECIFIC ANTISENSE OLIGONUCLEOTIDES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1999/010486    International Application No.:    PCT/US1998/017147
Publication Date: 04.03.1999 International Filing Date: 18.08.1998
Chapter 2 Demand Filed:    01.03.1999    
IPC:
A61K 38/00 (2006.01), C12N 15/11 (2006.01)
Applicants: HYBRIDON, INC. [US/US]; 155 Fortune Boulevard Milford, MA 01757 (US) (AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, CA, CF, CG, CH, CI, CM, CN, CU, CY, CZ, DE, DK, EE, ES, FI, FR, GA, GB, GE, GH, GM, GN, GR, GW, HU, ID, IE, IL, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MC, MD, MG, MK, ML, MN, MR, MW, MX, NE, NL, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW only).
CHEN, Jiandong [CN/US]; (US) (For US Only).
AGRAWAL, Sudhir [IN/US]; (US) (For US Only).
ZHANG, Ruiwen [CN/US]; (US) (For US Only)
Inventors: CHEN, Jiandong; (US).
AGRAWAL, Sudhir; (US).
ZHANG, Ruiwen; (US)
Agent: GREENFIELD, Michael, S.; McDonnell Boehnen Hulbert & Berghoff 300 South Wacker Drive Chicago, IL 60606 (US)
Priority Data:
08/916,384 22.08.1997 US
09/073,567 06.05.1998 US
Title (EN) MDM2-SPECIFIC ANTISENSE OLIGONUCLEOTIDES
(FR) OLIGONUCLEOTIDES ANTISENS SPECIFIQUES DU GENE MDM2
Abstract: front page image
(EN)The invention provides methods to activate tumor suppressors. The invention further provides antisense oligonucleotides complementary to a portion of the MDM2-encoding RNA and methods for using such antisense oligonucleotides as analytical and diagnostic tools, as potentiators of transgenic animal studies and for gene therapy approaches, and as potential therapeutic agents. The invention also provides methods to augment and synergistically activate a tumor suppressor in conjunction with the use of a DNA-damage inducing agent.
(FR)L'invention concerne des procédés d'activation de suppresseurs de tumeurs, des oligonucléotides antisens complémentaires d'une portion de l'ARN codant le gène MDM2, ainsi que des procédés d'utilisation de ces oligonucléotides en tant qu'instruments analytiques et diagnostiques, en tant que potentialisateurs utiles dans des études d'animaux transgéniques et dans des approches de thérapie génique, ainsi qu'en tant qu'agents thérapeutiques potentiels. L'invention concerne encore des procédés d'augmentation et d'activation synergique d'un suppresseur de tumeurs, utilisés conjointement avec un agent induisant un dommage à l'ADN.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)