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Machine translation
1. (WO1999010332) PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE BIOSYNTHESIS INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1999/010332    International Application No.:    PCT/US1998/017618
Publication Date: 04.03.1999 International Filing Date: 20.08.1998
Chapter 2 Demand Filed:    19.03.1999    
IPC:
C07D 237/14 (2006.01), C07D 237/18 (2006.01), C07D 237/20 (2006.01), C07D 409/04 (2006.01), C07F 9/6509 (2006.01)
Applicants: ABBOTT LABORATORIES [US/US]; CHAD 0377/AP6D-2, 100 Abbott Park Road, Abbott Park, IL 60064-3500 (US)
Inventors: BLACK, Lawrence, A.; (US)
Agent: WARD, Michael, J.; Abbott Laboratories, CHAD 0377/AP6D-2, 100 Abbott Park Road, Abbott Park, IL 60064-3500 (US)
Priority Data:
08/918,661 22.08.1997 US
Title (EN) PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE BIOSYNTHESIS INHIBITORS
(FR) INHIBITEURS DE LA BIOSYNTHESE DE LA PROSTAGLANDINE H2 SYNTHETASE
Abstract: front page image
(EN)The present invention describes pyridazinone compounds which are cyclooxygenase (COX) inhibitors, and in particular, are selective inhibitors of cyclooxygenase-2 (COX-2). COX-2 is the inducible isoform associated with inflammation, as opposed to the constitutive isoform, cyclooxygenase-1 (COX-1) which is an important 'housekeeping' enzyme in many tissues, including the gastrointestinal (GI) tract and the kidneys. The selectivity of these compounds for COX-2 minimizes the unwanted GI and renal side-effects seen with currently marketed non-steroidal anti-inflammatory drugs (NSAIDs).
(FR)La présente invention concerne des composés de pyridazinone inhibiteurs des cyclooxygénases (COX) et notamment des inhibiteurs sélectifs de la cyclooxygénase-2 (COX-2). COX-2 est l'isoforme inductible associée à l'inflammation, par opposition à l'isoforme constitutive, la cyclooxygénase-1 (COX-1), qui est une enzyme 'domestique' importante dans beaucoup de tissus, notamment le tractus gastro-intestinal (GI) et les reins. La sélectivité de ces composés vis-à-vis de COX-2 réduit les effets secondaires rénaux ou gastro-intestinaux des anti-inflammatoires non stéroïdiens (AINS) actuellement sur le marché.
Designated States: CA, JP, MX.
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE).
Publication Language: English (EN)
Filing Language: English (EN)