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1. (WO1999010321) ANTIMICROBIAL COMPOUNDS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1999/010321    International Application No.:    PCT/US1998/017830
Publication Date: 04.03.1999 International Filing Date: 28.08.1998
Chapter 2 Demand Filed:    29.03.1999    
IPC:
C07B 61/00 (2006.01), C07C 311/06 (2006.01), C07C 317/44 (2006.01)
Applicants: THE JOHNS HOPKINS UNIVERSITY [US/US]; 720 Rutland Avenue Baltimore, MD 21205 (US) (AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, CA, CF, CG, CH, CI, CM, CN, CU, CY, CZ, DE, DK, EE, ES, FI, FR, GA, GB, GE, GH, GM, GN, GR, GW, HU, ID, IE, IL, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MC, MD, MG, MK, ML, MN, MR, MW, MX, NE, NL, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW only).
TOWNSEND, Craig, A. [US/US]; (US) (For US Only).
DICK, James, D. [US/US]; (US) (For US Only).
PASTERNACK, Gary, R. [US/US]; (US) (For US Only).
KUHAJDA, Francis, P. [US/US]; (US) (For US Only).
PARRISH, Nicole, M. [US/US]; (US) (For US Only)
Inventors: TOWNSEND, Craig, A.; (US).
DICK, James, D.; (US).
PASTERNACK, Gary, R.; (US).
KUHAJDA, Francis, P.; (US).
PARRISH, Nicole, M.; (US)
Agent: POSORSKE, Laurence, H.; Baker & Botts, L.L.P. The Warner 1299 Pennsylvania Avenue, N.W. Washington, DC 20004 (US).
DEAN, John, Paul; Withers & Rogers Goldings House 2 Hays Lane London SE1 2HW (GB)
Priority Data:
60/056,272 29.08.1997 US
Title (EN) ANTIMICROBIAL COMPOUNDS
(FR) COMPOSES ANTIMICROBIENS
Abstract: front page image
(EN)This invention provides methods for treating a mycobacterial infection by administering to an animal a pharmaceutical composition containing a compound having the formula R-SO¿n?-Z-CO-Y, where R is an alkyl group having 6-20 carbons; Z is a radical selected from -CH¿2?-, -O-, and -NH-, two of these radicals coupled together, or -CH¿2?=CH¿2?-; Y is -NH¿2?, O-CH¿2?-C¿6?H¿5?, -CO-CO-O-CH¿3?, or O-CH¿3?; and n is 1 or 2. It has been discovered that these compounds inhibit growth of microbial cells which synthesize $g(a)-substitued, $g(b)-hydroxy fatty acids, particularly corynemycolic acid, nocardic acid, and mycolic acid. These compounds may be used to inhibit growth of mycobacterial cells, such as $i(Mycobacterium tuberculosis), drug-resistant $i(M. tuberculosis), $i(M. avium intracellulare), and $i(M. leprae).
(FR)L'invention concerne des traitements pour les infections à mycobactéries, comprenant l'administration à un animal d'une composition pharmaceutique contenant un composé représenté par la formule R-SO¿n?-Z-CO-Y, dans laquelle R est un groupe alkyle comprenant de 6 à 20 atomes de carbone; Z est un radical sélectionné parmi -CH¿2?-, -O- et -NH-, deux de ces radicaux assemblés ou -CH¿2?=CH¿2?-; Y est -NH¿2?, O-CH¿2?-C¿6?H¿5?, -CO-CO-O-CH¿3? ou O-CH¿3?; et n est 1 ou 2. On a découvert que ces composés inhibent le développement des cellules microbiennes qui synthétisent les acides gras $g(b)-hydroxy substitués en $g(a), en particulier l'acide corynemycolique, l'acide nocardique et l'acide mycolique. Ces composés peuvent êtres utilisés pour inhiber le développement de cellules mycobactériennes tells que $i(Mycobacterium tuberculosis), $i(M. tuberculosis) pharmacorésistant, $i(M. avium intracellulare) et $i(M. leprae).
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)