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1. (WO1999009912) INTRAVASCULAR APPARATUS AND METHOD
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1999/009912 International Application No.: PCT/US1998/016823
Publication Date: 04.03.1999 International Filing Date: 13.08.1998
Chapter 2 Demand Filed: 08.03.1999
IPC:
A61F 2/82 (2013.01) ,A61K 38/44 (2006.01) ,A61K 38/49 (2006.01) ,A61K 9/00 (2006.01) ,A61L 31/16 (2006.01) ,C12N 9/00 (2006.01) ,A61F 2/00 (2006.01) ,A61F 2/88 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
F
FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
2
Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
82
Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43
Enzymes; Proenzymes; Derivatives thereof
44
Oxidoreductases (1)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43
Enzymes; Proenzymes; Derivatives thereof
46
Hydrolases (3)
48
acting on peptide bonds (3.4)
49
Urokinase; Tissue plasminogen activator
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
31
Materials for other surgical articles
14
Materials characterised by their function or physical properties
16
Biologically active materials, e.g. therapeutic substances
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
F
FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
2
Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
F
FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
2
Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
82
Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
86
Stents in a form characterised by wire-like elements; Stents in a form characterised by a net-like or mesh-like structure
88
the wire-like elements formed as helical or spiral coils
Applicants:
TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD. [IL/IL]; Technion City 32000 Haifa, IL (AllExceptUS)
FRIEDMAN, Mark, M. [US/IL]; IL (TJ)
LOTAN, Noah [IL/IL]; IL (UsOnly)
DINNAR, Uri [IL/IL]; IL (UsOnly)
Inventors:
LOTAN, Noah; IL
DINNAR, Uri; IL
Common
Representative:
FRIEDMAN, Mark, M.; c/o Castorina, Anthony Suite 207 2001 Jefferson Davis Highway Arlington, VA 22202, US
Priority Data:
08/917,60926.08.1997US
Title (EN) INTRAVASCULAR APPARATUS AND METHOD
(FR) APPAREIL INTRAVASCULAIRE ET SON PROCEDE D'UTILISATION
Abstract:
(EN) Intravascular apparatus and method for locally treating a patient's blood vessel, are provided. The apparatus includes an implanted carrier (2) for insertion into the vessel; and a biologically active agent (8) immobilized to the carrier (2), said biologically active agent (8) reacting with a first substance to produce a second substance. The second substance is preferably a therapeutic agent, such as nitric oxide, for locally treating the vessel. The biologically active agent (8) is preferably an enzyme such as nitrogen oxide synthase, and the first substance is preferably arginine introduced to the patient's body as part of a diet. According to another embodiment, the biologically active agent (8) is a catalytic antibody and the first substance is a prodrug. Alternatively, the biologically active agent (8) is a ribozyme. The method includes introducing into a patient's vessel an implantable carrier including a biologically active agent immobilized thereto, and reacting the biologically active agent with a first substance to locally produce a second substance.
(FR) L'invention concerne un appareil intravasculaire et son procédé d'utilisation, lequel consiste à traiter localement un vaisseau sanguin d'un patient. L'appareil renferme un excipient implantable (2), destiné à être introduit dans ledit vaisseau, ainsi qu'un agent biologiquement actif (8) fixé audit excipient (2), cet agent biologiquement actif (8) réagissant avec une première substance afin de produire une seconde substance. Cette seconde substance est de préférence un agent thérapeutique, par exemple le monoxyde d'azote, destiné à traiter localement ledit vaisseau. L'agent biologiquement actif (8) est de préférence une enzyme telle que la monoxyde d'azote synthase, la première substance étant idéalement de l'arginine, introduite dans le corps dudit patient en tant que composante d'un régime alimentaire approprié. Dans un autre mode de réalisation, l'agent biologiquement actif (8) est un anticorps catalytique, et la première substance un promédicament. Dans une variante, ledit agent biologiquement actif (8) est une ribozyme. Selon le procédé de la présente invention, on introduit dans le vaisseau du patient un excipient implantable, renfermant un agent biologiquement actif fixé à cet excipient, puis on fait réagir cet agent biologiquement actif avec une première substance, de manière à produire localement une seconde substance.
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Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, HR, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
IL134696EP1045676US20020182750AU1998087007