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1. (WO1999009172) METHOD FOR IDENTIFYING AND LOCATING EXPRESSED EPIL PEPTIDES, CODED BY THE INSL4 GENE AND THEIR USES

Pub. No.:    WO/1999/009172    International Application No.:    PCT/FR1998/001799
Publication Date: Fri Feb 26 00:59:59 CET 1999 International Filing Date: Thu Aug 13 01:59:59 CEST 1998
IPC: A61K 38/00
C07K 14/64
C07K 16/26
G01N 33/68
G01N 33/74
Applicants: INSTITUT GUSTAVE-ROUSSY
BELLET, Dominique
TROALEN, Frédéric
BIDART, Jean-Michel
MOCK, Pascal
Inventors: BELLET, Dominique
TROALEN, Frédéric
BIDART, Jean-Michel
MOCK, Pascal
Title: METHOD FOR IDENTIFYING AND LOCATING EXPRESSED EPIL PEPTIDES, CODED BY THE INSL4 GENE AND THEIR USES
Abstract:
The invention concerns the identification and localisation in the tissue of novel polypeptides expressed by the insulin-like 4 gene (INSL4), their amino acid and nucleic acid sequence, detection and diagnosis methods, methods for marking, selecting and detecting cells expressing said polypeptides or their corresponding nucleic sequence and methods for selecting compounds capable of modulating the activity of said polypeptides. The invention also concerns medicines for treating tumours, such as Kaposi's Sarcoma, for the vascularization of specific tissues, tissue differentiation and/or regeneration, modulating embryonary implantation and treating pathologies related to insulin-like activity such as diabetes and its complications.