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1. (WO1999009021) PROCESS FOR SELECTIVE DERIVATIZATION OF TAXANES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1999/009021    International Application No.:    PCT/US1998/017016
Publication Date: 25.02.1999 International Filing Date: 17.08.1998
IPC:
C07D 305/14 (2006.01), C07F 7/18 (2006.01)
Applicants: FLORIDA STATE UNIVERSITY [US/US]; 100 Sliger Building, Innovation Park, Tallahassee, FL 32306-2763 (US)
Inventors: HOLTON, Robert, A.; (US).
ZHANG, Zhuming; (US).
CLARK, Paul, A.; (US)
Agent: HEJLEK, Edward, J.; Senniger, Powers, Leavitt & Roedel, 16th floor, One Metropolitan Square, St. Louis, MO 63102 (US)
Priority Data:
60/056,000 18.08.1997 US
60/081,265 09.04.1998 US
09/063,477 20.04.1998 US
Title (EN) PROCESS FOR SELECTIVE DERIVATIZATION OF TAXANES
(FR) PROCEDE DE DERIVATISATION SELECTIVE DE TAXANES
Abstract: front page image
(EN)Processes for the preparation of taxol and other taxanes through selective derivatization of the C(7) and C(10) hydroxyl groups of 10-DAB, particularly a novel process using a new strategy in which the C(10) hydroxyl group is protected or derivatized prior to the C(7) hydroxyl group; and the provision of C(7) and C(10) derivatized 10-DAB compounds.
(FR)L'invention concerne des procédés permettant de préparer du taxol et d'autres taxanes par dérivatisation sélective des groupes hydroxyles C(7) et C(10) de 10-DAB. L'invention concerne en particulier un nouveau procédé mettant en oeuvre une nouvelle stratégie selon laquelle le groupe hydroxyle C(10) est protégé ou dérivatisé avant le groupe C(7). L'invention traite également des composés 10-DAB dérivatisés de C(7) et C(10).
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)