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Machine translation
1. (WO1999009000) NOVEL INHIBITORS OF AGGRECANASE AND MATRIX METALLOPROTEINASES FOR THE TREATMENT OF ARTHRITIS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1999/009000    International Application No.:    PCT/US1998/017048
Publication Date: 25.02.1999 International Filing Date: 18.08.1998
Chapter 2 Demand Filed:    05.03.1999    
IPC:
C07C 259/06 (2006.01), C07C 271/22 (2006.01), C07C 311/06 (2006.01), C07C 311/08 (2006.01), C07C 311/16 (2006.01), C07C 311/21 (2006.01), C07D 257/04 (2006.01), C07D 295/155 (2006.01), C07D 295/205 (2006.01), C07D 307/79 (2006.01), C07D 317/60 (2006.01), C07D 413/04 (2006.01)
Applicants: DU PONT PHARMACEUTICALS COMPANY [US/US]; WR-1ST18 974 Centre Road Wilmington, DE 19807 (US)
Inventors: YAO, Wenqing; (US).
DECICCO, Carl, P.; (US)
Agent: KONRAD, Karen, H.; Du Pont Pharmaceuticals Company Legal Patent Records Center 1007 Market Street Wilmington, DE 19898 (US)
Priority Data:
60/055,944 18.08.1997 US
60/068,335 19.12.1997 US
Title (EN) NOVEL INHIBITORS OF AGGRECANASE AND MATRIX METALLOPROTEINASES FOR THE TREATMENT OF ARTHRITIS
(FR) NOUVEAUX INHIBITEURS DE L'AGGRECANASE ET DES METALLOPROTEINASES MATRICIELLES POUR LE TRAITEMENT DE L'ARTHRITE
Abstract: front page image
(EN)This invention relates to molecules which inhibit metalloproteinases such as formulas (I, IV) including aggrecanase, and the production of tumor necrosis factor (TNF). In particular, the compounds are inhibitors of metalloproteinases involved in tissue degradation and inhibitors of the release of tumor necrosis factor. The present invention also relates to pharmaceutical compositions comprising such compounds and to methods of using these compounds for the treatment of inflammatory diseases.
(FR)L'invention concerne des molécules qui inhibent les métalloprotéinases, y compris l'aggrécanase, ainsi que la production de facteur de nécrose tumoral. En particulier, les composés selon l'invention sont des inhibiteurs des métalloprotéinases, impliqués dans la dégradation tissulaire et des inhibiteurs de la libération du facteur de nécrose tumoral. La présente invention traite également de compositions pharmaceutiques comprenant ces composés, et de procédés mettant en oeuvre ces composés pour traiter les maladies inflammatoires.
Designated States: AU, BR, CA, CN, CZ, EE, HU, IL, JP, KR, LT, LV, MX, NO, NZ, PL, RO, SG, SI, SK, UA, VN.
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE).
Publication Language: English (EN)
Filing Language: English (EN)