WO1999008700 pRb2/p130 PEPTIDE INHIBITORS OF cdk2 KINASE ACTIVITY

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Publication Number WO/1999/008700

Publication Date 25.02.1999

International Application No. PCT/US1998/016381

International Filing Date 06.08.1998

Chapter 2 Demand Filed 19.03.1999

IPC

CPC

Applicants

THOMAS JEFFERSON UNIVERSITY [US]/[US]

Inventors

GIORDANO, Antonio

Agents

HEIDELBERGER, Louis M.

Priority Data

60/056,207

21.08.1997

Publication Language English (en)

Filing Language English (EN)

Designated States

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Title

(EN) pRb2/p130 PEPTIDE INHIBITORS OF cdk2 KINASE ACTIVITY

(FR) PEPTIDES DE pRb2/p130 INHIBITEURS DE L'ACTIVITE KINASE cdk2

Abstract

(EN) The present invention provides peptides of pRb2/p130 (see the Figure) or mutants or fragments thereof which inhibit cdk2 kinase activity. Methods of inhibiting cdk2 kinase activity in cells with these peptides are also provided.

(FR) La présente invention concerne des peptides de pRb2/p130 (voir figure) ou des mutants ou fragments de ceux-ci inhibant l'activité kinase cdk2. L'invention concerne également des procédés d'inhibition de l'activité kinase cdk2 dans des cellules à l'aide de ces peptides.

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N	MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9	Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
10	Transferases (2.)
12	transferring phosphorus containing groups, e.g. kinases (2.7)

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N	MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9	Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
10	Transferases (2.)
12	transferring phosphorus containing groups, e.g. kinases (2.7)

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35	Antineoplastic agents

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43	Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
2319	Fusion polypeptide

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1. WO1999008700 - pRb2/p130 PEPTIDE INHIBITORS OF cdk2 KINASE ACTIVITY