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1. WO1999008700 - pRb2/p130 PEPTIDE INHIBITORS OF cdk2 KINASE ACTIVITY

Publication Number WO/1999/008700
Publication Date 25.02.1999
International Application No. PCT/US1998/016381
International Filing Date 06.08.1998
Chapter 2 Demand Filed 19.03.1999
IPC
C12N 9/12 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
10Transferases (2.)
12transferring phosphorus containing groups, e.g. kinases (2.7)
CPC
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
C07K 2319/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2319Fusion polypeptide
C12N 9/1205
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes; Proenzymes; Compositions thereof
10Transferases (2.)
12transferring phosphorus containing groups, e.g. kinases (2.7)
1205Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
Applicants
  • THOMAS JEFFERSON UNIVERSITY [US]/[US]
Inventors
  • GIORDANO, Antonio
Agents
  • HEIDELBERGER, Louis M.
Priority Data
60/056,20721.08.1997US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) pRb2/p130 PEPTIDE INHIBITORS OF cdk2 KINASE ACTIVITY
(FR) PEPTIDES DE pRb2/p130 INHIBITEURS DE L'ACTIVITE KINASE cdk2
Abstract
(EN) The present invention provides peptides of pRb2/p130 (see the Figure) or mutants or fragments thereof which inhibit cdk2 kinase activity. Methods of inhibiting cdk2 kinase activity in cells with these peptides are also provided.
(FR) La présente invention concerne des peptides de pRb2/p130 (voir figure) ou des mutants ou fragments de ceux-ci inhibant l'activité kinase cdk2. L'invention concerne également des procédés d'inhibition de l'activité kinase cdk2 dans des cellules à l'aide de ces peptides.
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