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1. (WO1999008700) pRb2/p130 PEPTIDE INHIBITORS OF cdk2 KINASE ACTIVITY

Pub. No.:    WO/1999/008700    International Application No.:    PCT/US1998/016381
Publication Date: Fri Feb 26 00:59:59 CET 1999 International Filing Date: Fri Aug 07 01:59:59 CEST 1998
IPC: C12N 9/12
Applicants: THOMAS JEFFERSON UNIVERSITY
Inventors: GIORDANO, Antonio
Title: pRb2/p130 PEPTIDE INHIBITORS OF cdk2 KINASE ACTIVITY
Abstract:
The present invention provides peptides of pRb2/p130 (see the Figure) or mutants or fragments thereof which inhibit cdk2 kinase activity. Methods of inhibiting cdk2 kinase activity in cells with these peptides are also provided.