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1. (WO1999008533) CENTRAL NERVOUS SYSTEM AXON REGENERATION
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/1999/008533 International Application No.: PCT/US1998/016794
Publication Date: 25.02.1999 International Filing Date: 12.08.1998
Chapter 2 Demand Filed: 10.03.1999
IPC:
A61K 38/48 (2006.01) ,A61K 48/00 (2006.01) ,C07K 14/33 (2006.01) ,C12N 9/10 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43
Enzymes; Proenzymes; Derivatives thereof
46
Hydrolases (3)
48
acting on peptide bonds (3.4)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195
from bacteria
33
from Clostridium (G)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
10
Transferases (2.)
Applicants: STRITTMATTER, Stephen, M.[US/US]; US (UsOnly)
YALE UNIVERSITY[US/US]; Office of Cooperative Research 155 Whitney Avenue New Haven, CT 06520-8336, US (AT, AU, BE, CA, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, JP, LU, MC, NL, PT, SE)
Inventors: STRITTMATTER, Stephen, M.; US
Agent: KRINSKY, Mary, M.; 79 Trubull Street New Haven, CT 06511-9544, US
Priority Data:
60/055,26813.08.1997US
Title (EN) CENTRAL NERVOUS SYSTEM AXON REGENERATION
(FR) REGENERATION D'AXONES DANS LE SYSTEME NERVEUX CENTRAL
Abstract:
(EN) Therapies for the treatment of a variety of central nervous system injuries including acute or chronic spinal cord injury, traumatic brain injury, and white matter stroke involve the administration of rho protein inhibitors to promote axon regeneration. Local administration is employed in typical embodiments, and this may include injection of a recombinant virus that expresses an inhibitor. In one embodiment, the inhibitor is $i(C. botulinium) C3 exoenzyme or a chimeric $i(C. botulinum) C2/C3 construct expressed in a replication-deficient adeno, adeno-associated, or herpes virus.
(FR) Des thérapies permettant de traiter diverses lésions du système nerveux central y compris les lésions médulaires aigues ou chroniques, les lésions chromatiques du cerveau et les accidents vasculaires atteignant la substance blanche implique l'administration d'inhibiteurs de protéine rho pour activer la régénération des axones. Dans des formes de réalisations classiques, on utilise l'administration locale, cette dernière pouvant comprendre l'injection d'un virus de recombinaison qui exprime un inhibiteur. Dans une forme de réalisation, l'inhibiteur est la l'exoensyme C3 $i(C.botulinium) ou une structure C2/C3 $i(C.botulinum) chimérique exprimée dans un virus adéno déficient au niveau de la réplication, un virus adéno associé ou un virus associé.
Designated States: AU, CA, JP, US
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)