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1. WO1999008523 - METHODS FOR INHIBITING FIBROUS INFLAMMATORY DISEASE AND RIEDEL'S THYROIDITIS

Publication Number WO/1999/008523
Publication Date 25.02.1999
International Application No. PCT/US1998/016977
International Filing Date 17.08.1998
Chapter 2 Demand Filed 23.02.1999
IPC
A61K 31/4025 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
4025not condensed and containing further heterocyclic rings, e.g. cromakalim
A61K 31/4535 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
445Non-condensed piperidines, e.g. piperocaine
4523containing further heterocyclic ring systems
4535containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
A61K 31/55 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
55having seven-membered rings, e.g. azelastine, pentylenetetrazole
CPC
A61K 31/4025
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
4025not condensed and containing further heterocyclic rings, e.g. cromakalim
A61K 31/4535
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non condensed pyridines; Hydrogenated derivatives thereof
445Non condensed piperidines, e.g. piperocaine
4523containing further heterocyclic ring systems
4535containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
A61K 31/55
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
55having seven-membered rings, e.g. azelastine, pentylenetetrazole
Applicants
  • ELI LILLY AND COMPANY [US]/[US] (AL, AM, AU, AZ, BA, BB, BF, BG, BJ, BR, BY, CA, CF, CG, CI, CM, CN, CU, CZ, EE, GA, GE, GH, GM, GN, GW, HR, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LV, MD, MG, MK, ML, MN, MR, MW, MX, NE, NO, NZ, PL, RO, RU, SD, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW)
  • DODGE, Jeffrey, Alan [US]/[US] (UsOnly)
Inventors
  • DODGE, Jeffrey, Alan
Agents
  • SALES, James, J.
  • BOUDREAUX, William, R.
Priority Data
60/056,21421.08.1997US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS FOR INHIBITING FIBROUS INFLAMMATORY DISEASE AND RIEDEL'S THYROIDITIS
(FR) PROCEDE D'INHIBITION DES MALADIES INFLAMMATOIRES FIBROGENES ET DE LA THYROIDITE DE RIEDEL
Abstract
(EN)
A method of inhibiting Riedel's thyroiditis and fibrous inflammatory disease in a human which comprises the administration to a human in need thereof an effective amount of a compound of formula (I) wherein R1 and R3 are, independently, -H, -CH3, -CO(C1-C6 alkyl), or -COAr, where Ar is optionally substituted phenyl; R3 is selected from the group consisting of pyrrolidine, piperidine, and hexamethyleneimino; or a pharmaceutically acceptable salt or solvate thereof.
(FR)
L'invention porte sur un procédé d'inhibition chez l'homme de la thyroïdite de Riedel et des maladies inflammatoires fibrogènes consistant à administrer à un patient le nécessitant une dose efficace d'un composé de formule (I) dans laquelle: R1 et R3 sont indépendamment -H, -CH3, -CO(C1-C6 alkyle), ou -COAr où Ar est phényle facultativement substitué; R3 est sélectionné parmi pyrrolidine, pipéridine et hexaméthylénéimino, ou d'un de ses sels ou solvates pharmacocompatibles.
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