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1. (WO1999008522) STIMULATION, MODULATION AND/OR INHIBITION OF ENDOTHELIAL PROTEOLYTIC ACTIVITY AND/OR ANGIOGENIC ACTIVITY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1999/008522    International Application No.:    PCT/US1998/016816
Publication Date: 25.02.1999 International Filing Date: 14.08.1998
Chapter 2 Demand Filed:    15.03.1999    
IPC:
A61K 38/00 (2006.01), A61K 38/19 (2006.01), A61K 38/57 (2006.01), C07K 14/50 (2006.01), C07K 14/52 (2006.01), C07K 14/81 (2006.01), C07K 16/22 (2006.01), C07K 16/24 (2006.01)
Applicants: LUDWIG INSTITUTE FOR CANCER RESEARCH [US/US]; 605 Third Avenue New York, NY 10158 (US).
HELSINKI UNIVERSITY LICENSING LTD., OY. [FI/FI]; Viikinkaari 6 FIN-00710 Helsinki (FI).
UNIVERSITY OF GENEVA [CH/CH]; Medical Centre, Faculty of Medicine 1, rue Michel Servet CH-1211 Geneva 4 (CH)
Inventors: PEPPER, Michael, S.; (CH).
ALITALO, Kari; (FI).
ERIKSSON, Ulf; (SE)
Agent: EVANS, Joseph, D.; Evenson, McKeown, Edwards & Lenahan, P.L.L.C. Suite 700 1200 G Street, N.W. Washington, DC 20005 (US)
Priority Data:
60/055,868 15.08.1997 US
Title (EN) STIMULATION, MODULATION AND/OR INHIBITION OF ENDOTHELIAL PROTEOLYTIC ACTIVITY AND/OR ANGIOGENIC ACTIVITY
(FR) STIMULATION MODULATION ET/OU INHIBITION DE L'ACTIVITE PROTHEOLITHIQUE ENDOTHELIALE ET/OU DE L'ACTIVITE ANGIOGINIQUE
Abstract: front page image
(EN)Vascular endothelial growth factor-B (VEGF-B) and vascular endothelial growth factor-C (VEGF-C) are angiogenic polypeptides. It has been shown that VEGF-B and -C are angiogenic $i(in vitro) especially in combination with bFGF. VEGF-C also increases plasminogen activator (PA) activity in bovine endothelial cell lines and this is accompanied by a concomitant increase in PA inhibitor-1. Addition of alpha-2-antiplasmin to bovine endothelial cells co-treated with bFGF and VEGF-C partially inhibits collagen gel invasion.
(FR)Le facteur B de croissance endothéliale vasculaire (VEGF-B) et le facteur C de croissance endothéliale vasculaire (VEGF-C) sont des polypeptides angiogéniques. On a découvert que VEGF-B et VEGF-C sont angiogéniques $i(in vitro) plus particulièrement en combinaison avec b(FGF). VEGE-C augmente aussi l'activité des activateurs du plasminogène (PA) et ceci s'accompagne d'une augmentation correspondante de l'inhibiteur-1 PA. L'apport d'alpha-2-antiplasmine aux cellules endothéliales bovines traitées conjointement avec bFGF et VEGF-C permet d'inhiber partiellement l'invasion de gel collagène.
Designated States: AU, CA, CN, JP, KR, NZ.
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE).
Publication Language: English (EN)
Filing Language: English (EN)