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1. WO1999007870 - METHODS FOR GENETICALLY MODIFYING T CELLS

Publication Number WO/1999/007870
Publication Date 18.02.1999
International Application No. PCT/US1998/016598
International Filing Date 11.08.1998
Chapter 2 Demand Filed 20.01.1999
IPC
C12N 15/09 2006.1
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12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
C12N 15/86 2006.1
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15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
86Viral vectors
C12N 15/87 2006.1
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15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
C12N 5/0783 2010.1
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5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
078Cells from blood or from the immune system
0783T cells; NK cells; Progenitors of T or NK cells
CPC
C12N 15/86
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15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
86Viral vectors
C12N 15/87
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15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
C12N 2501/515
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2501Active agents used in cell culture processes, e.g. differentation
50Cell markers; Cell surface determinants
515CD3, T-cell receptor complex
C12N 2510/00
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2510Genetically modified cells
C12N 2740/13043
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2740Reverse Transcribing RNA Viruses
00011Reverse Transcribing RNA Viruses
10011Retroviridae
13011Gammaretrovirus, e.g. murine leukeamia virus
13041Use of virus, viral particle or viral elements as a vector
13043viral genome or elements thereof as genetic vector
C12N 2750/14143
CCHEMISTRY; METALLURGY
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2750ssDNA Viruses
00011ssDNA Viruses
14011Parvoviridae
14111Dependovirus, e.g. adenoassociated viruses
14141Use of virus, viral particle or viral elements as a vector
14143viral genome or elements thereof as genetic vector
Applicants
  • CHIRON CORPORATION [US]/[US]
Inventors
  • McLAUGHLIN-TAYLOR, Elizabeth
  • KRUGER, Mark
  • LUNDAK, Cheryl
  • KILLION, Catherine
Agents
  • SAVEREIDE, Paul, B.
Priority Data
60/055,45311.08.1997US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHODS FOR GENETICALLY MODIFYING T CELLS
(FR) METHODES DE MODIFICATION GENETIQUE DE LYMPHOCYTES T
Abstract
(EN) A method is provided for producing a population of genetically modified T cells. In the method, an $i(in vitro) population of T cells is activated by contacting said population with a CD3 binding agent. Genetic modification is then carried out with the activated T cells by contacting the same with a suitable gene transfer vector.
(FR) L'invention concerne une méthode de production d'une population de lymphocytes T génétiquement modifiés. Dans cette méthode, une population $i(in vitro) de lymphocytes T est activée par la mise en contact de ladite population avec un agent liant CD3. On réalise ensuite une modification génétique avec les lymphocytes T activés, en mettant ces mêmes en contact avec un vecteur de transfert génique convenable.
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