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Machine translation
1. (WO1999007843) HUMAN GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR PROMOTERS, VECTORS CONTAINING SAME, AND METHODS OF SCREENING COMPOUNDS THEREWITH
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1999/007843    International Application No.:    PCT/EP1998/004620
Publication Date: 18.02.1999 International Filing Date: 23.07.1998
Chapter 2 Demand Filed:    04.03.1999    
IPC:
A61K 38/00 (2006.01), C07K 14/475 (2006.01), C12N 15/85 (2006.01)
Applicants: F. HOFFMAN-LA ROCHE AG [CH/CH]; 124 Grenzacherstrasse, CH-4070 Basel (CH)
Inventors: BAECKER, Preston, Albert; (US).
JOHNSON, Randolph, Mellus; (US).
LEE, Walter, Hom; (US).
VERITY, Adrian, Neil; (US)
Agent: MEZGER, Wolfgang; 124 Grenzacherstrasse, CH-4070 Basel (CH).
WAECHTER, Dieter; 124 Grenzacherstrasse, CH-4070 Basle (CH)
Priority Data:
60/054,812 05.08.1997 US
60/081,751 14.04.1998 US
Title (EN) HUMAN GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR PROMOTERS, VECTORS CONTAINING SAME, AND METHODS OF SCREENING COMPOUNDS THEREWITH
(FR) PROMOTEURS DE GNDF HUMAINS, VECTEURS CONTENANT CES PROMOTEURS ET PROCEDES DE SELECTION DE COMPOSES UTILISANT CES PROMOTEURS
Abstract: front page image
(EN)The distal and proximal promoters for the human glial cell line-derived neurotrophic factor (GDNF) gene are provided. In addition, constructs comprising a human GDNF promoter and a reporter gene, a vector comprising the construct and a host cell comprising the vector are provided, as is a method for screening compounds capable of modulating the expression of GDNF by stimulating GDNF promoter-directed transcription.
(FR)L'invention concerne les promoteurs distaux et proximaux pour le gène du GDNF (glial celle line-derived neurotrophic factor). Elle concerne en outre des constructions comprenant un promoteur de GDNF humain et un gène marqueur, un vecteur comprenant cette construction et une cellule hôte comprenant le vecteur, ainsi qu'un procédé permettant de sélectionner des composés capables de moduler l'expression de GDNF en stimulant la transcription dirigée par le promoteur de GDNF.
Designated States: AU, CA, JP.
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE).
Publication Language: English (EN)
Filing Language: English (EN)