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1. (WO1999007741) MENINGOCOCCUS VACCINE COMPRISING THE VALENCE OF BZ83 STRAIN
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/1999/007741 International Application No.: PCT/FR1998/001730
Publication Date: 18.02.1999 International Filing Date: 03.08.1998
IPC:
A61K 38/00 (2006.01) ,C07K 14/22 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195
from bacteria
22
from Neisseriaceae (F), e.g. Acinetobacter
Applicants: QUENTIN-MILLET, Marie-José[FR/FR]; FR (UsOnly)
ROKBI, Bachra[FR/FR]; FR (UsOnly)
PASTEUR MERIEUX SERUMS & VACCINS[FR/FR]; 58, avenue Leclerc F-69007 Lyon, FR (AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, CA, CF, CG, CH, CI, CM, CN, CU, CY, CZ, DE, DK, EE, ES, FI, FR, GA, GB, GE, GH, GM, GN, GR, GW, HU, ID, IE, IL, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MC, MD, MG, MK, ML, MN, MR, MW, MX, NE, NL, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW)
Inventors: QUENTIN-MILLET, Marie-José; FR
ROKBI, Bachra; FR
Agent: AYROLES, Marie-Pauline; Pasteur Mérieux Sérums & Vaccins 58, avenue Leclerc F-69007 Lyon, FR
Priority Data:
97/1030107.08.1997FR
Title (EN) MENINGOCOCCUS VACCINE COMPRISING THE VALENCE OF BZ83 STRAIN
(FR) VACCIN MENINGOCOQUE COMPORTANT LA VALENCE DE SOUCHE BZ83
Abstract:
(EN) The invention concerns a pharmaceutical composition comprising (i) the subunit of least molecular weight (TbpB) of the human transferrin receptor (HTR) of a $i(Neisseria meningitis) strain having a DNA sequence coding for Tbp, (a) which contains two $i(Ava)II restriction sites, 3 $i(Hinc)II restriction sites, no $i(Vsp)I restriction site and no $i(Xho)I restriction site or (b) from which it is possible to generate by PCR (polymerase chain reaction) using primers P3 of formula 5'-AAGACCAAGGCGGATACGGTTTTGC-3' and P4 of formula 5'-GAAGACGAGTCGGAAACAAAGGGATG-3', a polynucleotide of 765 to 775 nucleotides. Such a strain is for example the BZ83 strain whereof the DNA sequence coding for TbpB is shown in the SEQ ID NO 1.
(FR) L'invention a pour objet une composition pharmaceutique comprenant (i) la sous-unité de moindre poids moléculaire (TbpB) du récepteur de la transferrine humaine (RTH) d'une souche de $i(Neisseria meningitidis) possédant une séquence d'ADN codant pour TbpB, (a) qui contient 2 sites de restriction $i(Ava)II, 3 sites de restriction $i(Hinc)II, aucun site de restriction $i(Vsp)I et aucun site de restriction $i(Xho)I ou (b) à partir de laquelle il est possible de générer par PCR (polymérase chain reaction) à l'aide des amorces P3 de formule 5'-AAGACCAAGGCGGATACGGTTTTGC-3' et P4 de formule 5'-GAAGACGAGTCGGAAACAAAGGGATG-3', un polynucléotide de 765 à 775 nucléotides. Une telle souche est par exemple la souche BZ83 dont la séquence d'ADN codant pour TbpB est montrée dans le SEQ ID NO 1.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG)
Publication Language: French (FR)
Filing Language: French (FR)