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1. (WO1999007739) DNA ENCODING THE HUMAN SYNAPSIN III GENE AND USES THEREOF

Pub. No.:    WO/1999/007739    International Application No.:    PCT/US1998/016375
Publication Date: Fri Feb 19 00:59:59 CET 1999 International Filing Date: Fri Aug 07 01:59:59 CEST 1998
IPC: A61K 38/00
C07K 14/47
Applicants: THE ROCKEFELLER UNIVERSITY
Inventors: GREENHARD, Paul
PORTON, Barbara
KAO, Hung-Teh
Title: DNA ENCODING THE HUMAN SYNAPSIN III GENE AND USES THEREOF
Abstract:
A new synapsin protein, designated synapsin III, its amino acid sequence, and its human gene have been isolated and characterized. Furthermore, isoforms of synapsin III, e.g., synapsin IIIa, IIIb and IIIc, and have been isolated and characterized, and cDNA encoding these isoforms has also been isolated and characterized. T he synapin III gene is located on human chromosome 22, in the vicinity of a region previously identified as a susceptibility locus for schizophrenia. The information and experimental tools provided by this discovery can be used to generate new therapeutic agents or diagnostic assays for this new protein, its associated mRNA or its associated genomic DNA. Due to its role in neurotransmission and synaptogenesis, isoforms of synapsin III are associated with the symptoms of psychiatric diseases, especially schizophrenia.