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1. WO1999007707 - 8-SUBSTITUTED-9H-1,3-DIOXOLO/4,5-h//2,3/BENZODIAZEPINE DERIVATIVES, AS AMPA/KAINATE RECEPTOR INHIBITORS

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Publication Number WO/1999/007707
Publication Date 18.02.1999
International Application No. PCT/HU1998/000075
International Filing Date 07.08.1998
Chapter 2 Demand Filed 02.03.1999
IPC
C07D 491/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
491Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/-C07D459/290
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
CPC
A61P 1/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
08for nausea, cinetosis or vertigo; Antiemetics
A61P 21/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
21Drugs for disorders of the muscular or neuromuscular system
02Muscle relaxants, e.g. for tetanus or cramps
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 25/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
06Antimigraine agents
A61P 25/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
08Antiepileptics; Anticonvulsants
A61P 25/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Applicants
  • EGIS GYÓGYSZERGYÁR RT. [HU]/[HU] (AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, CA, CF, CG, CH, CI, CM, CN, CU, CY, CZ, DE, DK, EE, ES, FI, FR, GA, GB, GE, GH, GM, GN, GR, GW, ID, IE, IL, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MC, MD, MG, MK, ML, MN, MR, MW, MX, NE, NL, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW)
  • RÁTKAI, Zoltán [HU]/[HU] (UsOnly)
  • BARKÓCZY, József [HU]/[HU] (UsOnly)
  • SCHNEIDER, Géza [HU]/[HU] (UsOnly)
  • CSELENYÁK, Judit [HU]/[HU] (UsOnly)
  • SIMIG, Gyula [HU]/[HU] (UsOnly)
  • BALÁZS, László [HU]/[HU] (UsOnly)
  • DOMÁN, Imre [HU]/[HU] (UsOnly)
  • GREFF, Zoltán [HU]/[HU] (UsOnly)
  • KÓTAY NAGY, Péter [HU]/[HU] (UsOnly)
  • SERES, Péter [HU]/[HU] (UsOnly)
  • SZABÓ, Géza [HU]/[HU] (UsOnly)
  • GACSÁLYI, István [HU]/[HU] (UsOnly)
  • GIGLER, Gábor [HU]/[HU] (UsOnly)
  • GYERTYÁN, István [HU]/[HU] (UsOnly)
  • LÉVAY, György [HU]/[HU] (UsOnly)
  • KOVÁCS, Attila [HU]/[HU] (UsOnly)
  • SIMÓ, Annamária [HU]/[HU] (UsOnly)
  • SZABADOS, Tamás [HU]/[HU] (UsOnly)
  • EGYED, András [HU]/[HU] (UsOnly)
  • VÉGH, Miklós [HU]/[HU] (UsOnly)
  • TIHANYI, Károly [HU]/[HU] (UsOnly)
Inventors
  • RÁTKAI, Zoltán
  • BARKÓCZY, József
  • SCHNEIDER, Géza
  • CSELENYÁK, Judit
  • SIMIG, Gyula
  • BALÁZS, László
  • DOMÁN, Imre
  • GREFF, Zoltán
  • KÓTAY NAGY, Péter
  • SERES, Péter
  • SZABÓ, Géza
  • GACSÁLYI, István
  • GIGLER, Gábor
  • GYERTYÁN, István
  • LÉVAY, György
  • KOVÁCS, Attila
  • SIMÓ, Annamária
  • SZABADOS, Tamás
  • EGYED, András
  • VÉGH, Miklós
  • TIHANYI, Károly
Agents
  • ADVOPATENT OFFICE OF PATENT AND TRADEMARK ATTORNEYS
Priority Data
P 97 0138012.08.1997HU
P 97 0138112.08.1997HU
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) 8-SUBSTITUTED-9H-1,3-DIOXOLO/4,5-h//2,3/BENZODIAZEPINE DERIVATIVES, AS AMPA/KAINATE RECEPTOR INHIBITORS
(FR) DERIVES DE 9H-1,3-DIOXOLO/4,5-h//2,3/BENZODIAZEPINE SUBSTITUEE EN HUIT UTILISES COMME INHIBITEURS DES RECEPTEURS D'AMPA/KAINATE
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Abstract
(EN) The invention refers to novel 8-substituted-9H-1,3-dioxolo/4,5-h//2,3/benzodiazepine derivatives of formula (I), a process for preparing these compounds and to pharmaceutical compositions containing these active substances. Compounds (I) inhibit Ampa/Kainate receptors.
(FR) L'invention concerne de nouveaux dérivés de 9H-1,3-dioxolo/4,5-h//2,3/benzodiazépine substituée en huit de formule (I), un procédé pour préparer ces composés, et des compositions pharmaceutiques contenant ces substances actives. Les composés (I) inhibent les récepteurs d'Ampa/Kainate.
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