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Machine translation
1. (WO1999007678) INDOLE DERIVATIVES AS MCP-1 RECEPTOR ANTAGONISTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1999/007678    International Application No.:    PCT/GB1998/002340
Publication Date: 18.02.1999 International Filing Date: 04.08.1998
Chapter 2 Demand Filed:    08.02.1999    
IPC:
C07D 209/42 (2006.01), C07D 409/12 (2006.01)
Applicants: ZENECA LIMITED [GB/GB]; 15 Stanhope Gate London W1Y 6LN (GB) (AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, CA, CF, CG, CH, CI, CM, CN, CU, CY, CZ, DE, DK, EE, ES, FI, FR, GA, GB, GE, GH, GM, GN, GR, GW, HR, HU, ID, IE, IL, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MC, MD, MG, MK, ML, MN, MR, MW, MX, NE, NL, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW only).
BARKER, Andrew, John [GB/GB]; (GB) (For US Only).
KETTLE, Jason, Grant [GB/GB]; (GB) (For US Only).
FAULL, Alan, Wellington [GB/GB]; (GB) (For US Only)
Inventors: BARKER, Andrew, John; (GB).
KETTLE, Jason, Grant; (GB).
FAULL, Alan, Wellington; (GB)
Agent: DENERLEY, Paul, Millington; Intellectual Property Dept. Zeneca Pharmaceuticals Mereside, Alderley Park Macclesfield Cheshire SK10 4TG (GB)
Priority Data:
9716656.5 07.08.1997 GB
Title (EN) INDOLE DERIVATIVES AS MCP-1 RECEPTOR ANTAGONISTS
(FR) DERIVES D'INDOLE UTILES EN TANT QU'ANTAGONISTES DU RECEPTEUR MCP-1
Abstract: front page image
(EN)The invention concerns pharmaceutically useful indoles of formula (I), in which Z, X, T, A, R?1¿, R?2¿, p and q have any of the meanings defined herein, and their pharmaceutically acceptable salts or $i(in vivo) hydrolysable esters, as well as pharmaceutical compositions containing them. The novel compounds possess inhibitory activity against monocyte chemoattractant protein-1 (MCP-1). The invention further concerns the use of such indoles in the treatment of a disease or condition mediated by MCP-1.
(FR)Cette invention concerne des indoles utiles du point de vue pharmaceutique correspondant à la formule (I). Dans la formule Z, X, T, A, R?1¿, R?2¿, p et q sont tels qu'ils sont définis dans l'invention. Cette invention concerne également les sels pharmaceutiquement acceptables de ces indoles ou bien leurs esters hydrolysables $i(in vivo), ainsi que des compositions pharmaceutiques contenant ces derniers. Ces nouveaux composés présentent une activité inhibitrice contre la protéine 1 chimiotactique de monocyte (MCP-1). Cette invention concerne également l'utilisation de ces indoles dans le traitement d'une maladie ou d'une pathologie induite par MCP-1.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, HR, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)