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1. (WO1999007383) COMPOSITION AND METHOD FOR REGULATING CELL PROLIFERATION AND CELL DEATH
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/1999/007383 International Application No.: PCT/CA1998/000744
Publication Date: 18.02.1999 International Filing Date: 05.08.1998
Chapter 2 Demand Filed: 23.02.1999
IPC:
A61K 47/48 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
48
the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
Applicants: BIONICHE INC.[CA/CA]; 383 Sovereign Road London, Ontario N6M 1A3, CA
Inventors: PHILLIPS, Nigel, C.; CA
FILION, Mario, C.; CA
Agent: CAMPBELL, Hugh, D.; Finlayson & Singlehurst 70 Gloucester Street Ottawa, Ontario K2P OA2, CA
Priority Data:
60/054,77705.08.1997US
60/075,06718.02.1998US
60/075,11118.02.1998US
60/086,31721.05.1998US
Title (EN) COMPOSITION AND METHOD FOR REGULATING CELL PROLIFERATION AND CELL DEATH
(FR) COMPOSITION ET PROCEDE DE REGULATION DE LA PROLIFERATION ET DE LA MORT DES CELLULES
Abstract:
(EN) The present invention relates to a composition and method useful for regulating cell proliferation and cell death in a multicellular organism. The present invention particularly relates to a composition comprising a bacterial DNA (B-DNA) and a first pharmaceutically acceptable carrier, wherein the B-DNA induces a response in responsive cells of an animal. The present invention more particularly relates to a composition comprising a mycobacterial DNA (M-DNA) and a first pharmaceutically acceptable carrier, wherein the M-DNA inhibits proliferation of responsive cells of an animal, induces apoptosis in responsive cells of an animal, and stimulattes responsive cells of the immune system of an animal to produce bioactive molecules. Methods of making the M-DNA composition and methods of using the M-DNA composition also are disclosed.
(FR) La présente invention concerne une composition et un procédé permettant, chez les organismes pluricellulaires, de réguler la prolifération et la mort des cellules. L'invention concerne notamment une composition comprenant de l'ADN bactérien (ADN-B) et un premier vecteur pharmaceutiquement admis, l'ADN-B induisant une réponse au niveau des cellules réceptives d'un animal. L'invention concerne plus particulièrement une composition comprenant de l'ADN mycobactérien (ADN-M) et un premier vecteur pharmaceutiquement admis. En l'occurrence, l'ADN-M inhibe la prolifération des cellules réceptives d'un animal, induit l'apoptose au niveau des cellules réceptives d'un animal, et stimule les cellules réceptives du système immunitaire de l'animal pour qu'elles produisent des molécules bioactives. L'invention concerne enfin des procédés de fabrication de la composition d'ADN-M, et des procédés d'utilisation de cette composition d'ADN-M.
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Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, HR, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)