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1. WO1999007382 - MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS FOR USE IN THE TREATMENT OF CARDIOVASCULAR DISEASES

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Publication Number WO/1999/007382
Publication Date 18.02.1999
International Application No. PCT/US1998/016374
International Filing Date 06.08.1998
Chapter 2 Demand Filed 08.02.1999
IPC
A61K 31/60 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
60Salicylic acid; Derivatives thereof
A61K 31/609 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
60Salicylic acid; Derivatives thereof
609Amides, e.g. salicylamide
A61P 9/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
C07C 65/40 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
65Compounds having carboxyl groups bound to carbon atoms of six-membered aromatic rings and containing any of the groups OH, O-metal, -CHO, keto, ether, groups, groups, or groups
32containing keto groups
40containing singly bound oxygen-containing groups
CPC
A61K 31/609
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
60Salicylic acid; Derivatives thereof
609Amides, e.g. salicylamide
A61P 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
Applicants
  • SMITHKLINE BEECHAM CORPORATION [US]/[US] (AT, BE, CA, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, JP, LU, MC, NL, PT, SE)
  • LYSKO, Paul, G. [US]/[US] (UsOnly)
  • WEINSTOCK, Joseph [US]/[US] (UsOnly)
Inventors
  • LYSKO, Paul, G.
  • WEINSTOCK, Joseph
Agents
  • SIMON, Soma, G.
Priority Data
60/055,39706.08.1997US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS FOR USE IN THE TREATMENT OF CARDIOVASCULAR DISEASES
(FR) ANTAGONISTES DES RECEPTEURS DES MONOCYTES MACROPHAGES POUVANT ETRE UTILISES POUR TRAITER LES MALADIES VASCULAIRES
Abstract
(EN) Salicylanilide derivatives which are macrophage scavenger receptor antagonists are provided. Methods of treating cardiovascular disease comprising administration of the present compounds are also provided. The present compounds inhibit lipid accumulation within macrophage-derived foam cells.
(FR) L'invention concerne des dérivés de salicylanilide qui sont des antagonistes des récepteurs des monocytes macrophages. L'invention traite également de procédés permettant de traiter des maladies cardiovasculaires, et consistant à administrer les composés selon l'invention qui inhibent l'accumulation des lipides dans les cellules spumeuses dérivées des macrophages.
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