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1. (WO1999007378) NICOTINE ANTAGONISTS FOR NICOTINE-RESPONSIVE NEUROPSYCHIATRIC DISORDERS

Pub. No.:    WO/1999/007378    International Application No.:    PCT/US1998/016634
Publication Date: Fri Feb 19 00:59:59 CET 1999 International Filing Date: Wed Aug 12 01:59:59 CEST 1998
IPC: A61K 31/00
A61K 31/13
A61K 31/14
A61K 31/4035
A61K 31/437
A61K 31/4745
A61K 45/06
Applicants: THE UNIVERSITY OF SOUTH FLORIDA A Corporation of the State of Florida
SANBERG, Paul, Ronald
SHYTLE, Roland, Douglas
SILVER, Archie, Aaron
Inventors: SANBERG, Paul, Ronald
SHYTLE, Roland, Douglas
SILVER, Archie, Aaron
Title: NICOTINE ANTAGONISTS FOR NICOTINE-RESPONSIVE NEUROPSYCHIATRIC DISORDERS
Abstract:
Nicotine-responsive neuropsychiatric disorders can be treated by administering a nicotine antagonist, particularly mecamylamine. Combination therapy of mecamylamine with a neuroleptic drug also is disclosed. The neuropsychiatric disorders include Tourette's syndrome, schizophrenia, depression, bipolar disorder, tremors, attention deficit hyperactivity disorder, obsessive-compulsive disorder, hemidystonia, rage outbursts and tardive dyskinesia.