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1. (WO1999007367) ASYMMETRIC CONJUGATE ADDITION REACTION

Pub. No.:    WO/1999/007367    International Application No.:    PCT/US1998/016251
Publication Date: Fri Feb 19 00:59:59 CET 1999 International Filing Date: Wed Aug 05 01:59:59 CEST 1998
IPC: C07D 405/04
C07D 405/06
C07D 413/14
Applicants: MERCK & CO., INC.
DEVINE, Paul, N.
HEID, Richard, M., Jr.
TILLYER, Richard, D.
TSCHAEN, David, M.
Inventors: DEVINE, Paul, N.
HEID, Richard, M., Jr.
TILLYER, Richard, D.
TSCHAEN, David, M.
Title: ASYMMETRIC CONJUGATE ADDITION REACTION
Abstract:
This invention relates to a key intermediate in the synthesis of an endothelin antagonist the synthesis of this key intermediate via an asymmetric conjugate addition reaction.