Processing

Please wait...

Settings

Settings

Goto Application

1. WO1999007343 - INJECTABLE BIODEGRADABLE BLOCK COPOLYMER GELS FOR USE IN DRUG DELIVERY

Publication Number WO/1999/007343
Publication Date 18.02.1999
International Application No. PCT/US1998/016418
International Filing Date 08.08.1998
Chapter 2 Demand Filed 08.03.1999
IPC
A61K 9/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
A61K 9/107 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
107Emulsions
A61K 9/51 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
50Microcapsules
51Nanocapsules
A61K 47/34 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
C08L 71/02 2006.1
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
71Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
02Polyalkylene oxides
CPC
A61K 47/30
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
A61K 47/34
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
A61K 9/0024
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
A61K 9/1075
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
107Emulsions ; ; Emulsion preconcentrates; Micelles
1075Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
C08L 71/02
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
71Compositions of polyethers obtained by reactions forming an ether link in the main chain
02Polyalkylene oxides
Applicants
  • UNIVERSITY OF UTAH RESEARCH FOUNDATION [US]/[US]
Inventors
  • JEONG, Byeongmoon
  • BAE, You, Han
  • LEE, Doo, Sung
  • KIM, Sung, Wan
Agents
  • WESTERN, M., Wayne
Priority Data
09/130,96707.08.1998US
60/055,17408.08.1997US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) INJECTABLE BIODEGRADABLE BLOCK COPOLYMER GELS FOR USE IN DRUG DELIVERY
(FR) COPOLYMERES BLOCS EN GELS INJECTABLES ET BIODEGRADABLES SERVANT A ADMINISTRER UN MEDICAMENT
Abstract
(EN) A system and method for the parenteral delivery of a drug in a biodegradable polymeric matrix to a warm blooded animal as an aqueous liquid with the resultant formation of a hydrogel depot for the controlled release of the drug. The system comprises an injectable biodegradable block copolymeric drug delivery liquid having thermal gelation properties. The copolymer has a gel/sol transition temperature such that, above the body temperature of the animal to which it is administered, it is a solution and when administered and cooled to body temperature it forms a hydrogel. The copolymer is made up of (i) a hydrophobic A polymer block of poly ($g(a)-hydroxy acid) and (ii) a hydrophilic B polymer block comprising a poly(ethylene oxide). The drug is released at a controlled rate from the copolymer which biodegrades into non-toxic products. The gel/sol transition temperature and degradation rate can be adjusted by proper selection of the molecular weight and concentration of the poly ($g(a)-hydroxy acid) and poly(ethylene oxide) polymer block components.
(FR) Système et procédé servant à administrer par voie parentérale un médicament contenu dans une matrice polymère biodégradable à un animal à sang chaud, sous forme de liquide aqueux provoquant un dépôt d'hydrogel permettant d'effectuer la libération contrôlée du médicament. Ce système est composé d'un copolymère bloc sous forme liquide biodégradable et injectable servant à administrer le médicament. Ce copolymère possède une température de transition de gel à sol, de façon à constituer une solution, au-dessus de la température du corps de l'animal auquel on l'administre, et à constituer un hydrogel quand on l'administre et qu'on le refroidit à la température du corps. Ce copolymère est constitué par (i) un polymère bloc A hydrophobe de poly($g(a)-hydroxy acide) et par (ii) un polymère bloc B hydrophile contenant un oxyde de polyéthylène. Le médicament est libéré à une vitesse contrôlé depuis le copolymère qui se dégrade biologiquement en produits non toxiques. On peut régler la température de transition de gel à sol et la vitesse de dégradation par sélection adéquate du poids moléculaire et de la concentration des constituants du polymère bloc de poly($g(a)-hydroxy acide) et d'oxyde de polyéthylène.
Latest bibliographic data on file with the International Bureau