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1. (WO1999006576) A HUMAN GLANDULAR KALLIKREIN ENHANCER, VECTORS COMPRISING THE ENHANCER AND METHODS OF USE THEREOF

Pub. No.:    WO/1999/006576    International Application No.:    PCT/US1998/016312
Publication Date: Feb 11, 1999 International Filing Date: Aug 4, 1998
IPC: A61K 48/00
C07K 14/075
C12N 15/861
Applicants: CALYDON, INC.
YU, De-Chao
HERDENSON, Daniel, R.
SCHUUR, Eric, R.
Inventors: YU, De-Chao
HERDENSON, Daniel, R.
SCHUUR, Eric, R.
Title: A HUMAN GLANDULAR KALLIKREIN ENHANCER, VECTORS COMPRISING THE ENHANCER AND METHODS OF USE THEREOF
Abstract:
Enhancers which preferentially increase the transcription of cis-linked coding sequences in prostate cells are provided. Methods of using DNA constructs comprising the enhancers to control transcription of heterologous polynucleotides are also provided. Delivery vehicles comprising the enhancers and methods of using the vehicles are also provided. Adenovirus vectors in which one or more genes are under transcriptional control of the enhancers of the invention are also provided. Further provided are methods of using the adenovirus vectors of the invention to confer selective cytotoxicity in mammalian cells.