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1. WO1999006437 - SULFONYLATED DIPEPTIDE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4

Publication Number WO/1999/006437
Publication Date 11.02.1999
International Application No. PCT/US1998/016070
International Filing Date 31.07.1998
Chapter 2 Demand Filed 19.02.1999
IPC
A61K 38/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 5/06 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
06Dipeptides
C07K 5/078 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
06Dipeptides
078the first amino acid being heterocyclic, e.g. Pro, His, Trp
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
A61P 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
C07K 5/06139
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
06Dipeptides
06139with the first amino acid being heterocyclic
C07K 5/06165
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
06Dipeptides
06139with the first amino acid being heterocyclic
06165and Pro-amino acid; Derivatives thereof
Applicants
  • ELAN PHARMACEUTICALS INC. [US]/[US] (AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, CA, CF, CG, CH, CI, CM, CN, CU, CY, CZ, DE, DK, EE, ES, FI, FR, GA, GB, GE, GH, GM, GN, GR, GW, HR, HU, ID, IE, IL, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MC, MD, MG, MK, ML, MN, MR, MW, MX, NE, NL, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW)
  • AMERICAN HOME PRODUCTS CORPORATION [US]/[US] (AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, CA, CF, CG, CH, CI, CM, CN, CU, CY, CZ, DE, DK, EE, ES, FI, FR, GA, GB, GE, GH, GM, GN, GR, GW, HR, HU, ID, IE, IL, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MC, MD, MG, MK, ML, MN, MR, MW, MX, NE, NL, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW)
  • THORSETT, Eugene, D. [US]/[US] (UsOnly)
  • SEMKO, Christopher, M. [CA]/[US] (UsOnly)
  • PLEISS, Michael, A. [US]/[US] (UsOnly)
  • KREFT, Anthony [US]/[US] (UsOnly)
  • KONRADI, Andrei, W. [US]/[US] (UsOnly)
  • GRANT, Francine, S. [FR]/[US] (UsOnly)
  • BAUDY, Reinhardt, Bernhard [DE]/[US] (UsOnly)
  • SARANTAKIS, Dimitrios [US]/[US] (UsOnly)
Inventors
  • THORSETT, Eugene, D.
  • SEMKO, Christopher, M.
  • PLEISS, Michael, A.
  • KREFT, Anthony
  • KONRADI, Andrei, W.
  • GRANT, Francine, S.
  • BAUDY, Reinhardt, Bernhard
  • SARANTAKIS, Dimitrios
Agents
  • SWISS, Gerald, F.
Priority Data
08/904,42331.07.1997US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) SULFONYLATED DIPEPTIDE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4
(FR) COMPOSES DIPEPTIDIQUES SULFONYLES INHIBITEURS DE L'ADHESION DES LEUCOCYTES INDUITE PAR VLA-4
Abstract
(EN) Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
(FR) Cette invention concerne des composés qui se lient à l'intégrine VLA-4. Certains de ces composés inhibent également l'adhésion des leucocytes et, en particulier, l'adhésion des leucocytes induite par la VLA-4. Ces composés sont utilisés pour traiter des maladies inflammatoires chez un patient mammifère, par exemple, un être humain. Parmi ces maladies, on trouve l'asthme, la maladie d'Alzheimer, l'athérosclérose, le complexe démentiel du SIDA, le diabète, l'affection intestinale inflammatoire, la polyarthrite rhumatoïde, la transplantation de tissus, la métastase tumorale et l'ischémie myocardique. Ces composés peuvent également être administrés pour traiter des maladies cérébrales inflammatoires telles que la sclérose en plaques.
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