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1. (WO1999006437) SULFONYLATED DIPEPTIDE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1999/006437    International Application No.:    PCT/US1998/016070
Publication Date: 11.02.1999 International Filing Date: 31.07.1998
Chapter 2 Demand Filed:    19.02.1999    
IPC:
A61K 38/00 (2006.01), C07K 5/06 (2006.01), C07K 5/078 (2006.01)
Applicants: ELAN PHARMACEUTICALS INC. [US/US]; 800 Gateway Boulevard South San Francisco, CA 94080 (US) (AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, CA, CF, CG, CH, CI, CM, CN, CU, CY, CZ, DE, DK, EE, ES, FI, FR, GA, GB, GE, GH, GM, GN, GR, GW, HR, HU, ID, IE, IL, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MC, MD, MG, MK, ML, MN, MR, MW, MX, NE, NL, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW only).
AMERICAN HOME PRODUCTS CORPORATION [US/US]; 5 Giraldi Farms Madison, NJ 07940 (US) (AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, CA, CF, CG, CH, CI, CM, CN, CU, CY, CZ, DE, DK, EE, ES, FI, FR, GA, GB, GE, GH, GM, GN, GR, GW, HR, HU, ID, IE, IL, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MC, MD, MG, MK, ML, MN, MR, MW, MX, NE, NL, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW only).
THORSETT, Eugene, D. [US/US]; (US) (For US Only).
SEMKO, Christopher, M. [CA/US]; (US) (For US Only).
PLEISS, Michael, A. [US/US]; (US) (For US Only).
KREFT, Anthony [US/US]; (US) (For US Only).
KONRADI, Andrei, W. [US/US]; (US) (For US Only).
GRANT, Francine, S. [FR/US]; (US) (For US Only).
BAUDY, Reinhardt, Bernhard [DE/US]; (US) (For US Only).
SARANTAKIS, Dimitrios [US/US]; (US) (For US Only)
Inventors: THORSETT, Eugene, D.; (US).
SEMKO, Christopher, M.; (US).
PLEISS, Michael, A.; (US).
KREFT, Anthony; (US).
KONRADI, Andrei, W.; (US).
GRANT, Francine, S.; (US).
BAUDY, Reinhardt, Bernhard; (US).
SARANTAKIS, Dimitrios; (US)
Agent: SWISS, Gerald, F.; Burns, Doane, Swecker & Mathis, L.L.P. P.O. Box 1404 Alexandria, VA 22313-1404 (US)
Priority Data:
08/904,423 31.07.1997 US
Title (EN) SULFONYLATED DIPEPTIDE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4
(FR) COMPOSES DIPEPTIDIQUES SULFONYLES INHIBITEURS DE L'ADHESION DES LEUCOCYTES INDUITE PAR VLA-4
Abstract: front page image
(EN)Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
(FR)Cette invention concerne des composés qui se lient à l'intégrine VLA-4. Certains de ces composés inhibent également l'adhésion des leucocytes et, en particulier, l'adhésion des leucocytes induite par la VLA-4. Ces composés sont utilisés pour traiter des maladies inflammatoires chez un patient mammifère, par exemple, un être humain. Parmi ces maladies, on trouve l'asthme, la maladie d'Alzheimer, l'athérosclérose, le complexe démentiel du SIDA, le diabète, l'affection intestinale inflammatoire, la polyarthrite rhumatoïde, la transplantation de tissus, la métastase tumorale et l'ischémie myocardique. Ces composés peuvent également être administrés pour traiter des maladies cérébrales inflammatoires telles que la sclérose en plaques.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, HR, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)