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1. (WO1999006437) SULFONYLATED DIPEPTIDE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4

Pub. No.:    WO/1999/006437    International Application No.:    PCT/US1998/016070
Publication Date: Fri Feb 12 00:59:59 CET 1999 International Filing Date: Sat Aug 01 01:59:59 CEST 1998
IPC: A61K 38/00
C07K 5/06
C07K 5/078
Applicants: ELAN PHARMACEUTICALS INC.
AMERICAN HOME PRODUCTS CORPORATION
THORSETT, Eugene, D.
SEMKO, Christopher, M.
PLEISS, Michael, A.
KREFT, Anthony
KONRADI, Andrei, W.
GRANT, Francine, S.
BAUDY, Reinhardt, Bernhard
SARANTAKIS, Dimitrios
Inventors: THORSETT, Eugene, D.
SEMKO, Christopher, M.
PLEISS, Michael, A.
KREFT, Anthony
KONRADI, Andrei, W.
GRANT, Francine, S.
BAUDY, Reinhardt, Bernhard
SARANTAKIS, Dimitrios
Title: SULFONYLATED DIPEPTIDE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4
Abstract:
Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.