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1. (WO1999006432) DIPEPTIDE AND RELATED COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4

Pub. No.:    WO/1999/006432    International Application No.:    PCT/US1998/015325
Publication Date: Feb 11, 1999 International Filing Date: Jul 31, 1998
IPC: A61K 38/00
C07K 5/06
C07K 5/072
C07K 5/078
Applicants: ELAN PHARMACEUTICALS, INC.
AMERICAN HOME PRODUCTS CORPORATION
THORSETT, Eugene, D.
SEMKO, Christopher, M.
PLEISS, Michael, A.
LOMBARDO, Louis, John
GRANT, Francine, S.
DRESSEN, Darren, B.
DAPPEN, Michael, S.
Inventors: THORSETT, Eugene, D.
SEMKO, Christopher, M.
PLEISS, Michael, A.
LOMBARDO, Louis, John
GRANT, Francine, S.
DRESSEN, Darren, B.
DAPPEN, Michael, S.
Title: DIPEPTIDE AND RELATED COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4
Abstract:
Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brains diseases such as multiple sclerosis.