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1. (WO1999006406) 4-OXO-3,5-DIHYDRO-4H-PYRIDAZINO[4,5-b]-INDOLE-1-ACETAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY

Pub. No.:    WO/1999/006406    International Application No.:    PCT/FR1998/001667
Publication Date: Fri Feb 12 00:59:59 CET 1999 International Filing Date: Wed Jul 29 01:59:59 CEST 1998
IPC: C07D 487/04
Applicants: SANOFI-SYNTHELABO
EVANNO, Yannick
DUBOIS, Laurent
SEVRIN, Mireille
MARGUET, Frank
FROISSANT, Jacques
BARTSCH, Régine
GILLE, Catherine
Inventors: EVANNO, Yannick
DUBOIS, Laurent
SEVRIN, Mireille
MARGUET, Frank
FROISSANT, Jacques
BARTSCH, Régine
GILLE, Catherine
Title: 4-OXO-3,5-DIHYDRO-4H-PYRIDAZINO[4,5-b]-INDOLE-1-ACETAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY
Abstract:
The invention concerns compounds of general formula (I) in which: X represents a hydrogen or halogen atom or a methyl, methoxy or phenylmethoxy group; Y represents a hydrogen atom, one or two halogen atoms or a methyl, hydroxy, methoxy or nitro group; R1 represents a hydrogen atom or a (C1-C4) alkyl group; R2 and R3 represent each, independently of each other, a hydrogen atom, a (C1-C4) alkyl group or a phenyl-methyl group; or R2 and R3 form, together with the nitrogen atom bearing them, an azetidinyl, pyrrolidinyl, 3-ethoxy-pyrrolidinyl, piperidinyl, morpholinyl, 4-methylpiperazinyl or 1,3-thiazolidinyl group. They can be used for treating diseases related to GABAergic transmission disorders.