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1. (WO1999006401) 2-ARYL-2,5-DIHYDRO-PYRAZOLO[4,3-c]QUINOLIN-3-ONES AS GABA ALPHA 5 RECEPTOR INVERSE AGONISTS

Pub. No.:    WO/1999/006401    International Application No.:    PCT/GB1998/002290
Publication Date: Feb 11, 1999 International Filing Date: Jul 30, 1998
IPC: C07D 471/04
Applicants: MERCK SHARP & DOHME LIMITED
BOURRAIN, Sylvie
BRYANT, Helen, Jane
MACLEOD, Angus, Murray
SHOWELL, Graham, Andrew
Inventors: BOURRAIN, Sylvie
BRYANT, Helen, Jane
MACLEOD, Angus, Murray
SHOWELL, Graham, Andrew
Title: 2-ARYL-2,5-DIHYDRO-PYRAZOLO[4,3-c]QUINOLIN-3-ONES AS GABA ALPHA 5 RECEPTOR INVERSE AGONISTS
Abstract:
Certain 2-aryl-2,5-dihydro- pyrazolo[4,3-c] quinolin-3-ones of formula (I) are disclosed, in which the aryl group and optionally the quinoline ring are substituted in a defined manner. The compounds are selective inverse agonists at GABAα5 receptors, and are useful in treatments for the enhancement of cognition, particularly in subjects suffering from Alzheimer's disease.