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1. (WO1999006037) NOVEL DIARYLSULFONE NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS

Pub. No.:    WO/1999/006037    International Application No.:    PCT/US1998/015577
Publication Date: Fri Feb 12 00:59:59 CET 1999 International Filing Date: Thu Jul 30 01:59:59 CEST 1998
IPC: C07C 311/21
C07C 311/29
C07D 215/36
C07D 215/58
Applicants: UNIVERSITY OF THE SCIENCES IN PHILADELPHIA
Inventors: ZANGER, Murray
Title: NOVEL DIARYLSULFONE NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS
Abstract:
In accordance with the present invention, there is now provided novel anti-HIV compounds of formulae selected from the group consisting of: (I), (II), (III), (IV) and (V) wherein R1 is hydrogen or C1-C4 alkyl; R2 is hydrogen, C1-C4 alkyl, C1-C4 alkoxy or halogen; R3 is hydrogen, hydroxy, C1-C4 alkyl, C1-C4 alkoxy or halogen; R4 is hydrogen or halogen; R5 is hydrogen; C1-C4 alkoxy, nitro, halogen or haloalkyl; R6 is hydrogen or nitro; R7 is hydrogen or C1-C4 alkyl, C1-C4 alkoxy, nitro or halogen; R8 is hydrogen, hydroxy, C1-C4 alkyl, C1-C4 alkoxy or halogen; R9 is hydrogen or nitro; R10 is hydrogen or halogen; R11 is hydrogen, C1-C4 amin; R12 is hydrogen, C1-C4 alkyl or halogen; R13 is hydrogen, C1-C4 amin; R14 is hydrogen or halogen; R15 is hydrogen, C1-C4 alkoxy, C1-C4 haloalkyl, nitro, or halogen; R16 is hydrogen or nitro; R17 is hydrogen, C1-C4 alkyl, C1-C4 alkoxy, nitro or halogen; R18 is hydrogen, C1-C4 alkoxy, hydroxy, or halogen; R19 is hydrogen or nitro; R20 is hydrogen or halogen, and R21 is hydrogen or NO2 or a pharmaceutically acceptable salt thereof.