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1. (WO1999006037) NOVEL DIARYLSULFONE NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1999/006037    International Application No.:    PCT/US1998/015577
Publication Date: 11.02.1999 International Filing Date: 29.07.1998
Chapter 2 Demand Filed:    26.02.1999    
IPC:
C07C 311/21 (2006.01), C07C 311/29 (2006.01), C07D 215/36 (2006.01), C07D 215/58 (2006.01)
Applicants: UNIVERSITY OF THE SCIENCES IN PHILADELPHIA [US/US]; 600 South Forty-Third Street Philadelphia, PA 19104-4495 (US)
Inventors: ZANGER, Murray; (US)
Agent: LUTHER, John, P.; Duane, Morris & Heckscher LLP One Liberty Place Philadelphia, PA 19103-7396 (US)
Priority Data:
08/901,919 29.07.1997 US
Title (EN) NOVEL DIARYLSULFONE NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS
(FR) DIARYLSULFONES INHIBANT LA TRANSCRIPTASE INVERSE DU VIH ET CONSTITUANT DE NOUVEAUX INHIBITEURS NON NUCLEOSIDES DU VIRUS DE L'IMMUNODEFICIENCE HUMAINE
Abstract: front page image
(EN)In accordance with the present invention, there is now provided novel anti-HIV compounds of formulae selected from the group consisting of: (I), (II), (III), (IV) and (V) wherein R¿1? is hydrogen or C¿1?-C¿4? alkyl; R¿2? is hydrogen, C¿1?-C¿4? alkyl, C¿1?-C¿4? alkoxy or halogen; R¿3? is hydrogen, hydroxy, C¿1?-C¿4? alkyl, C¿1?-C¿4? alkoxy or halogen; R¿4? is hydrogen or halogen; R¿5? is hydrogen; C¿1?-C¿4? alkoxy, nitro, halogen or haloalkyl; R¿6? is hydrogen or nitro; R¿7? is hydrogen or C¿1?-C¿4? alkyl, C¿1?-C¿4? alkoxy, nitro or halogen; R¿8? is hydrogen, hydroxy, C¿1?-C¿4? alkyl, C¿1?-C¿4? alkoxy or halogen; R¿9? is hydrogen or nitro; R¿10? is hydrogen or halogen; R¿11? is hydrogen, C¿1?-C¿4? amin; R¿12? is hydrogen, C¿1?-C¿4? alkyl or halogen; R¿13? is hydrogen, C¿1?-C¿4? amin; R¿14? is hydrogen or halogen; R¿15? is hydrogen, C¿1?-C¿4? alkoxy, C¿1?-C¿4? haloalkyl, nitro, or halogen; R¿16? is hydrogen or nitro; R¿17? is hydrogen, C¿1?-C¿4? alkyl, C¿1?-C¿4? alkoxy, nitro or halogen; R¿18? is hydrogen, C¿1?-C¿4? alkoxy, hydroxy, or halogen; R¿19? is hydrogen or nitro; R¿20? is hydrogen or halogen, and R¿21? is hydrogen or NO¿2? or a pharmaceutically acceptable salt thereof.
(FR)Cette invention se rapporte à de nouveaux composés anti-VIH, représentés par l'une des formules (I), (II), (III), (IV) et (V), ou à un sel pharmaceutiquement acceptable de ces composés. Dans les formules susmentionnées, R¿1? est hydrogène ou alkyle C¿1?-C¿4?; R¿2? est hydrogène, alkyle C¿1?-C¿4?, alcoxy C¿1?-C¿4? ou halogène; R¿3? est hydrogène, hydroxy, alkyle C¿1?-C¿4?, alcoxy C¿1?-C¿4? ou halogène; R¿4? est hydrogène ou halogène, R¿5? est hydrogène, alcoxy C¿1?-C¿4?, nitro, halogène ou haloalkyle; R¿6? est hydrogène ou nitro; R¿7? est hydrogène, alkyle C¿1?-C¿4?, alcoxy C¿1?-C¿4?, nitro ou halogène; R¿8? est hydrogène, hydroxy, alkyle C¿1?-C¿4?, alcoxy C¿1?-C¿4? ou halogène; R¿9? est hydrogène ou nitro; R¿10? est hydrogène ou halogène; R¿11? est hydrogène, amine C¿1?-C¿4?; R¿12? est hydrogène, alkyle C¿1?-C¿4? ou halogène; R¿13? est hydrogène, amine C¿1?-C¿4?; R¿14? est hydrogène ou halogène; R¿15? est hydrogène, alcoxy C¿1?-C¿4?, haloalkyle C¿1?-C¿4?, nitro ou halogène; R¿16? est hydrogène ou nitro; R¿17? est hydrogène, alkyle C¿1?-C¿4?, alcoxy C¿1?-C¿4?, nitro ou halogène; R¿18? est hydrogène, alcoxy C¿1?-C¿4?, hydroxy ou halogène; R¿19? est hydrogène ou nitro; R¿20? est hydrogène ou halogène, et R¿21? est hydrogène ou NO¿2?.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, HR, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)