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1. (WO1999006031) PHARMACEUTICAL FORMULATION FOR CAMPTOTHECIN ANALOGUES IN GELATIN CAPSULE
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/1999/006031 International Application No.: PCT/US1998/015908
Publication Date: 11.02.1999 International Filing Date: 30.07.1998
Chapter 2 Demand Filed: 16.02.1999
IPC:
A61K 9/48 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
48
Preparations in capsules, e.g. of gelatin, of chocolate
Applicants:
CHRISTENSEN, Gregory, A. [US/US]; US (UsOnly)
PATEL, Kamlesh [US/US]; US (UsOnly)
PALEPU, Nageswara, R. [US/US]; US (UsOnly)
SMITHKLINE BEECHAM CORPORATION [US/US]; One Franklin Plaza Philadelphia, PA 19103, US (AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, CA, CF, CG, CH, CI, CM, CN, CY, CZ, DE, DK, EE, ES, FI, FR, GA, GB, GE, GH, GM, GN, GR, GW, HU, ID, IE, IL, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MC, MD, MG, MK, ML, MN, MR, MW, MX, NE, NL, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW)
HERZYK, Danuta [US/US]; US (UsOnly)
Inventors:
CHRISTENSEN, Gregory, A.; US
PATEL, Kamlesh; US
PALEPU, Nageswara, R.; US
HERZYK, Tomasz; null
Agent:
STERCHO, Yuriy, P. ; SmithKline Beecham Corporation Corporate Intellectual Property, UW2220 709 Swedeland Road P.O. Box 1539 King of Prussia, PA 19406-0939, US
Priority Data:
08/904,76101.08.1997US
Title (EN) PHARMACEUTICAL FORMULATION FOR CAMPTOTHECIN ANALOGUES IN GELATIN CAPSULE
(FR) PREPARATION PHARMACEUTIQUE POUR ANALOGUES DE CAMPTOTHECINE DANS UNE GELULE
Abstract:
(EN) The invention relates to a stable topotecan pharmaceutical composition in the form of a gelatin capsule. The invention specifically provides a hydrophobic matrix for formulation with topotecan HC1 that is dispersed so as to minimize any chemical reaction between the active drug, the excipients and ambient moisture.
(FR) L'invention concerne une composition pharmaceutique de topotécan stable qui se présente sous forme d'une gélule. L'invention concerne en particulier une matrice hydrophobe destinée à une préparation contenant du HCP de topotécan qui est dispersé de manière à réduire au maximum toute réaction chimique entre le médicament actif, les excipients et l'humidité ambiante.
Designated States: AL, AU, BA, BB, BG, BR, CA, CN, CZ, EE, GE, HU, ID, IL, IS, JP, KP, KR, LC, LK, LR, LT, LV, MG, MK, MN, MX, NO, NZ, PL, RO, SG, SI, SK, SL, TR, TT, UA, US, UZ, VN, YU
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)