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1. (WO1999006006) RUBBER PLUG FOR MEDICAL SERVICE

Pub. No.:    WO/1999/006006    International Application No.:    PCT/JP1998/003218
Publication Date: Fri Feb 12 00:59:59 CET 1999 International Filing Date: Sat Jul 18 01:59:59 CEST 1998
IPC: A61J 1/00
B65D 51/00
B65D 51/24
Applicants: ELI LILLY JAPAN KABUSHIKI KAISHA

NISHIKAWA, Kazuo

OKAMOTO, Tetsuya

Inventors: NISHIKAWA, Kazuo

OKAMOTO, Tetsuya

Title: RUBBER PLUG FOR MEDICAL SERVICE
Abstract:
A rubber plug (2) provided with a leg (4) fitted into the mouth of a vial (1) and a flange (6) in contact with an upper edge surface (5) of the vial mouth, wherein projections (8) for preventing close contact of a top face (7) of a head of the rubber plug (2) are shaped into an arcuate shape and positioned at the portions of the upper edge surface (5) on the outer side of the inner diameter of the vial mouth so that the lower parts of the arcuate projections (8) of the top face (7) come into contact with the upper edge surface (5) on the outer side of the vial mouth and compressive deformation of the arcuate projections (8) is suppressed with the upper edge surface (5) acting as the base. When a pharmaceutical preparation is freeze-dried in a vacuum inside the vial (1), the top face (7) does not completely contact the push surface of the freeze-drying rack when the rubber plug (2) is inserted, and a space is defined between the push surface and the top face (7) of the rubber plug (2) and a close contact can be prevented.