Search International and National Patent Collections

1. (WO1999005263) ANTI-INVASIVE AND ANTI-ANGIOGENIC UROKINASE FRAGMENTS AND THEIR USE

Pub. No.:    WO/1999/005263    International Application No.:    PCT/US1998/015437
Publication Date: Feb 4, 1999 International Filing Date: Jul 24, 1998
IPC: A61K 38/00
C12N 9/72
Applicants: ANGSTROM PHARMACEUTICALS, INC.
JONES, Terence, R.
MAZAR, Andrew, P.
Inventors: JONES, Terence, R.
MAZAR, Andrew, P.
Title: ANTI-INVASIVE AND ANTI-ANGIOGENIC UROKINASE FRAGMENTS AND THEIR USE
Abstract:
A peptide compound having the sequence Lys-Pro-Ser-Ser-Pro-Pro-Glu-Glu [SEQ ID NO:2] or a substitution variant, addition variant or other chemical derivative thereof inhibits cell invasion, endothelial tube formation or angiogenesis in vitro. A number of substitution variants and addition variants of this peptide, preferably capped at the N- and C-termini, as well as peptidomimetic derivatives, are useful for treating diseases and conditions mediated by undesired and uncontrolled cell invasion and/or angiogenesis. Pharmaceutical compositions comprising the above peptides and derivatives are administered to subjects in need of such treatment in a dosage sufficient to inhibit invasion and/or angiogenesis. The disclosed compositions and methods are particularly useful for suppressing the growth and metastasis of tumors.