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1. (WO1999005255) METHODS FOR ENHANCING OR REDUCING PREIMPLANTATION EMBRYO SURVIVAL RATES

Pub. No.:    WO/1999/005255    International Application No.:    PCT/US1998/015124
Publication Date: Fri Feb 05 00:59:59 CET 1999 International Filing Date: Thu Jul 23 01:59:59 CEST 1998
IPC: A61K 38/00
C07K 14/47
C07K 14/74
Applicants: NORTHEASTERN UNIVERSITY
WARNER, Carol, M.
McELHINNY, Abigail, S.
Inventors: WARNER, Carol, M.
McELHINNY, Abigail, S.
Title: METHODS FOR ENHANCING OR REDUCING PREIMPLANTATION EMBRYO SURVIVAL RATES
Abstract:
The present invention relates to the use of 'protein painting' (the addition of exogenous, lipid-modified proteins) to improve embryonic viability, development, and implantation. It is shown here that a lipid-modified protein, e.g., GPI-modified exogenous Qa-2 protein, spontaneously incorporates into the plasma membrane of B6.K1 T cells and onto Ped slow preimplantation embryos. It is also shown that, given enough time after incorporation, the exogenous Qa-2 protein increases the rate of development of early embryos cultured in vitro, most likely by diffusing in the plasma membrane until it is 'connected' to its functional signaling machinery. Protein painting of embryos has the potential, therefore, to be a valuable tool in enhancing embryo development and implantation.