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1. (WO1999005162) METHODS OF MODIFYING THE BUTYROPHILIN PROTEIN TO ELIMINATE AN AUTOIMMUNE RESPONSE AND PRODUCTS ASSOCIATED THEREWITH

Pub. No.:    WO/1999/005162    International Application No.:    PCT/US1998/015062
Publication Date: Fri Feb 05 00:59:59 CET 1999 International Filing Date: Thu Jul 23 01:59:59 CEST 1998
IPC: A61K 38/00
C07K 14/705
Applicants: UNIVERSITY OF MARYLAND
MATHER, Ian, H.
LININGTON, Christopher
Inventors: MATHER, Ian, H.
LININGTON, Christopher
Title: METHODS OF MODIFYING THE BUTYROPHILIN PROTEIN TO ELIMINATE AN AUTOIMMUNE RESPONSE AND PRODUCTS ASSOCIATED THEREWITH
Abstract:
The invention is directed to altering the N-terminal amino acid sequence of butyrophilin to eliminate an autoimmune response, diagnostics for identifying individuals susceptible to an autoimmune response triggered by ingesting butyrophilin, and genetically engineered mammals capable of expressing butyrophilin void of amino acid sequences that elicit a cross-reactive immune response to myelin oligodendrocyte glycoprotein.