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1. (WO1999005146) HYPONATREMIA REMEDIES

Pub. No.:    WO/1999/005146    International Application No.:    PCT/JP1998/000800
Publication Date: Fri Feb 05 00:59:59 CET 1999 International Filing Date: Fri Feb 27 00:59:59 CET 1998
IPC: A61K 31/435
C07D 489/00
Applicants: TORAY INDUSTRIES, INC.

NAGASE, Hiroshi

UENO, Koki

HAGIMOTO, Koji

ENDOH, Takashi

TANAKA, Toshiaki

KAWAMURA, Kuniaki

SHIRAKI, Motohiro

Inventors: NAGASE, Hiroshi

UENO, Koki

HAGIMOTO, Koji

ENDOH, Takashi

TANAKA, Toshiaki

KAWAMURA, Kuniaki

SHIRAKI, Motohiro

Title: HYPONATREMIA REMEDIES
Abstract:
Hyponatremia remedies containing as the active ingredient opioid λ receptor agonists represented by general formula (I) or the like; and a method of treatment therewith. The agonists exhibit both the property as a hydragogue diuretic of specifically excreting water and the effect of keeping blood sodium level, which is not linked up with the diuretic action, and cause only negligible adverse effects, thus being ideal hyponatremia remedies useful for the drug therapy of hyponatremia.