Search International and National Patent Collections

1. (WO1999005134) SUBSTITUTED 1,2,3,4-TETRAHYDRONAPHTHALENE DERIVATIVES

Pub. No.:    WO/1999/005134    International Application No.:    PCT/SE1998/001390
Publication Date: Fri Feb 05 00:59:59 CET 1999 International Filing Date: Thu Jul 16 01:59:59 CEST 1998
IPC: C07C 237/24
C07D 295/135
C07D 295/155
C07D 295/192
C07D 295/205
Applicants: ASTRA AKTIEBOLAG
BERG, Stefan
LINDERBERG, Mats
ROSS, Svante
THORBERG, Seth-Olov
ULFF, Bengt
Inventors: BERG, Stefan
LINDERBERG, Mats
ROSS, Svante
THORBERG, Seth-Olov
ULFF, Bengt
Title: SUBSTITUTED 1,2,3,4-TETRAHYDRONAPHTHALENE DERIVATIVES
Abstract:
The present invention relates to new piperidyl-or piperazinyl-substituted-1,2,3,4-tetrahydronaphthalene derivatives having formula (I) wherein X is N or CH; Y is NR2CH2, CH2-NR2, NR2-CO, CO-NR2 or NR2SO2 wherein R2 is H or C1-C6 alkyl; R1 is H, C1-C6 alkyl or C3-C6 cycloalkyl; R3 is C1-C6 alkyl, C3-C6 cycloalkyl or (CH2)n-aryl, wherein aryl is phenyl or a heteroaromatic ring containing one or two heteroatoms selected from N, O and S and which may be mono- or di-substituted, n is 0-4; R9 is C1-C6 alkyl, C3-C6 cycloalkyl, OCF3, OCHF2, OCH2F, halogen, CN, CF3, OH, C1-C6 alkoxy, C1-C6 alkoxy C1-C6 alkyl, NR6R7, SO3CH3, SO3CF3, SO2NR6R7, an unsubstituted or substituted heterocyclic or heteroaromatic ring containing one or two heteroatoms selected from N and O, wherein the substituent(s) is(are) C1-C6 alkyl; or COR8; wherein R6, R7 and R8 are as defined above, as (R)-enantiomers, (S)-enantiomers or racemates in the form of a free base or pharmaceutically acceptable salts thereof, a process for their preparation, pharmaceutical compositions containing said therapeutically active compounds and to the use of said active compounds in therapy.