WO1999005107 VITRONECTIN RECEPTOR ANTAGONIST

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Publication Number WO/1999/005107

Publication Date 04.02.1999

International Application No. PCT/US1998/015271

International Filing Date 23.07.1998

Chapter 2 Demand Filed 17.02.1999

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Applicants

SMITHKLINE BEECHAM CORPORATION [US]/[US] (AT, BE, CA, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, JP, LU, MC, NL, PT, SE)
KU, Thomas, W. [US]/[US] (UsOnly)

Inventors

KU, Thomas, W.

Agents

MCCARTHY, Mary, E.

Priority Data

60/053,789

25.07.1997

Publication Language English (en)

Filing Language English (EN)

Designated States

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Title

(EN) VITRONECTIN RECEPTOR ANTAGONIST

(FR) ANTAGONISTES DU RECEPTEUR DE VITRONECTINE

Abstract

(EN) Compounds of formula (I) are disclosed which are vitronectin receptor antagonists and are useful in the treatment of osteoporosis, or a pharmaceutically acceptable salt thereof.

(FR) Composés représentés par la formule (I), antagonistes du récepteur de vitronectine et utiles pour traiter l'ostéoporose, ou un de leurs sels acceptables sur le plan pharmaceutique.

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
C	ACYCLIC OR CARBOCYCLIC COMPOUNDS
69	Esters of carboxylic acids; Esters of carbonic or haloformic acids
66	Esters of carboxylic acids having esterified carboxyl groups bound to acyclic carbon atoms and having any of the groups OH, O-metal, -CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
73	of unsaturated acids
738	Esters of keto-carboxylic acids

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
213	Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02	having three double bonds between ring members or between ring members and non-ring members
04	having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
60	with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
72	Nitrogen atoms
74	Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
C	ACYCLIC OR CARBOCYCLIC COMPOUNDS
69	Esters of carboxylic acids; Esters of carbonic or haloformic acids
66	Esters of carboxylic acids having esterified carboxyl groups bound to acyclic carbon atoms and having any of the groups OH, O-metal, -CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
73	of unsaturated acids
738	Esters of keto-carboxylic acids

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
213	Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02	having three double bonds between ring members or between ring members and non-ring members
04	having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
60	with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
72	Nitrogen atoms
74	Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11	Drugs for disorders of the respiratory system

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1. WO1999005107 - VITRONECTIN RECEPTOR ANTAGONIST