Search International and National Patent Collections

1. (WO1999005103) 2O(S)-7-ETHYL-9-(N-METHYL-N-PHENYL)AMIDINO-CAMPTOTHECIN, ITS PREPARATION AND ITS USE AS ANTITUMOR AGENT

Pub. No.:    WO/1999/005103    International Application No.:    PCT/EP1998/004919
Publication Date: Fri Feb 05 00:59:59 CET 1999 International Filing Date: Tue Jul 21 01:59:59 CEST 1998
IPC: A61K 31/47
A61K 31/4745
A61P 35/00
C07D 491/22
Applicants: PHARMACIA & UPJOHN S.P.A.
BEDESCHI, Angelo
CABRI, Walter
CANDIANI, Ilaria
CAPOLONGO, Laura
Inventors: BEDESCHI, Angelo
CABRI, Walter
CANDIANI, Ilaria
CAPOLONGO, Laura
Title: 2O(S)-7-ETHYL-9-(N-METHYL-N-PHENYL)AMIDINO-CAMPTOTHECIN, ITS PREPARATION AND ITS USE AS ANTITUMOR AGENT
Abstract:
A water soluble camptothecin derivative which is 20(S)-7-ethyl-9-(N-methyl-N-phenyl)amidino-camptothecin (I) and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing them and a process for their preparation are described. The compound of the invention and its pharmaceutically acceptable salts are useful antitumor agents and are further characterised by having a remarkable therapeutic index.