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1. (WO1999004794) CYCLIC AMINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1999/004794    International Application No.:    PCT/US1998/014990
Publication Date: 04.02.1999 International Filing Date: 21.07.1998
Chapter 2 Demand Filed:    05.02.1999    
IPC:
A61K 31/445 (2006.01), A61K 31/4453 (2006.01), A61K 31/4468 (2006.01), A61K 31/45 (2006.01), A61K 31/451 (2006.01), A61K 31/4525 (2006.01), A61K 31/4535 (2006.01), A61K 31/454 (2006.01), A61K 31/4545 (2006.01), A61K 31/498 (2006.01), A61K 31/517 (2006.01), A61K 31/535 (2006.01), A61K 31/5375 (2006.01), A61K 31/5377 (2006.01), A61K 31/538 (2006.01), A61P 9/10 (2006.01), A61P 11/06 (2006.01), A61P 19/02 (2006.01), A61P 29/00 (2006.01), A61P 31/18 (2006.01), A61P 37/04 (2006.01), A61P 37/08 (2006.01), A61P 43/00 (2006.01), C07D 211/14 (2006.01), C07D 211/18 (2006.01), C07D 211/22 (2006.01), C07D 211/32 (2006.01), C07D 211/34 (2006.01), C07D 211/52 (2006.01), C07D 211/58 (2006.01), C07D 211/64 (2006.01), C07D 211/76 (2006.01), C07D 295/12 (2006.01), C07D 401/04 (2006.01), C07D 401/06 (2006.01), C07D 401/12 (2006.01), C07D 403/04 (2006.01), C07D 405/06 (2006.01), C07D 405/12 (2006.01), C07D 407/04 (2006.01), C07D 409/06 (2006.01), C07D 409/12 (2006.01), C07D 413/04 (2006.01), C07D 471/10 (2006.01)
Applicants: MERCK & CO., INC. [US/US]; 126 East Lincoln Avenue, Rahway, NJ 07065 (US) (For All Designated States Except US).
CALDWELL, Charles, G. [US/US]; (US) (For US Only).
FINKE, Paul, E. [US/US]; (US) (For US Only).
MacCOSS, Malcolm [GB/US]; (US) (For US Only).
MEURER, Laura, C. [US/US]; (US) (For US Only).
MILLS, Sander, G. [US/US]; (US) (For US Only).
OATES, Bryan [US/US]; (US) (For US Only)
Inventors: CALDWELL, Charles, G.; (US).
FINKE, Paul, E.; (US).
MacCOSS, Malcolm; (US).
MEURER, Laura, C.; (US).
MILLS, Sander, G.; (US).
OATES, Bryan; (US)
Common
Representative:
MERCK & CO., INC.; 126 East Lincoln Avenue, Rahway, NJ 07065 (US)
Priority Data:
60/053,754 25.07.1997 US
9800958.2 16.01.1998 GB
Title (EN) CYCLIC AMINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
(FR) AMINES CYCLIQUES MODULANT L'ACTIVITE DES RECEPTEURS DE CHIMIOKINES
Abstract: front page image
(EN)The present invention is directed to cyclic amines of formula (I), (wherein R?1¿, R?2¿, R?3¿, m and n are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-1, CCR-2, CCR-2A, CCR-2B, CCR-3, CCR-4, CCR-5, CXCR-3, and/or CXCR-4.
(FR)La présente invention se rapporte à des amines cycliques représentées par la formule (I), dans laquelle R?1¿, R?2¿, R?3¿, m et n sont définis dans le descriptif de l'invention. Ces amines s'avèrent utiles en tant que modulateurs de l'activité des récepteurs de chimiokines, et notamment des récepteurs CCR-1, CCR-2, CCR2A, CCR-2B, CCR-3, CCR-4, CCR-5, CXCR-3 et/ou CXCR-4.
Designated States: AL, AM, AU, AZ, BA, BB, BG, BR, BY, CA, CN, CU, CZ, EE, GE, HR, HU, ID, IL, IS, JP, KG, KR, KZ, LC, LK, LR, LT, LV, MD, MG, MK, MN, MX, NO, NZ, PL, RO, RU, SG, SI, SK, SL, TJ, TM, TR, TT, UA, US, UZ, VN, YU.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)