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1. WO1999003854 - CRYSTAL MODIFICATION OF A N-PHENYL-2-PYRIMIDINEAMINE DERIVATIVE, PROCESSES FOR ITS MANUFACTURE AND ITS USE

Publication Number WO/1999/003854
Publication Date 28.01.1999
International Application No. PCT/EP1998/004427
International Filing Date 16.07.1998
Chapter 2 Demand Filed 18.12.1998
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
C07D 401/04 (2006.01)
CPC
C07D 401/04
C30B 7/00
Applicants
  • NOVARTIS AG [CH/CH]; Schwarzwaldallee 215 CH-4058 Basel, CH (AL, AM, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, CA, CF, CG, CH, CI, CM, CN, CU, CY, CZ, DE, DK, EE, ES, FI, FR, GA, GB, GE, GH, GM, GN, GR, GW, HR, HU, ID, IE, IL, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MC, MD, MG, MK, ML, MN, MR, MW, MX, NE, NL, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW)
  • NOVARTIS-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH [AT/AT]; Brunner Strasse 59 A-1235 Vienna, AT (AT)
  • ZIMMERMANN, Jürg [CH/CH]; CH (UsOnly)
  • SUTTER, Bertrand [FR/FR]; FR (UsOnly)
  • BÜRGER, Hans, Michael [DE/CH]; CH (UsOnly)
Inventors
  • ZIMMERMANN, Jürg; CH
  • SUTTER, Bertrand; FR
  • BÜRGER, Hans, Michael; CH
Agents
  • BECKER, Konrad; Novartis AG Patent- und Markenabteilung Lichtstrasse 35 CH-4002 Basel, CH
Priority Data
1764/9718.07.1997CH
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) CRYSTAL MODIFICATION OF A N-PHENYL-2-PYRIMIDINEAMINE DERIVATIVE, PROCESSES FOR ITS MANUFACTURE AND ITS USE
(FR) MODIFICATION DE LA FORME CRISTALLINE D'UN DERIVE N-PHENYL-2-PYRIMIDINEAMINE, PROCEDE DE PREPARATION ET D'UTILISATION DE CE DERNIER
Abstract
(EN)
The invention relates to a new crystalline form of the methanesulfonic acid addition salt of 4-(4-methylpiperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl)pyrimidin-2-ylamino)phenyl]-benzamide of formula (I), which may be used for example for tumour therapy.
(FR)
Cette invention concerne une nouvelle forme cristalline du sel d'addition acide du méthane sulfonique de 4-(4-méthylepiperazine-1-ylméthyle)-N-[4-méthyle-3-(4-pyridine-3-yl)pyrimidine-2-ylamino)phényle]-benzamide de formule (I) qui peut être utilisée par exemple pour la thérapie antitumorale.
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