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1. WO1999001567 - METHODS AND COMPOSITIONS FOR A DEUBIQUITINATING ENZYME AND VARIANTS THEREOF

Publication Number WO/1999/001567
Publication Date 14.01.1999
International Application No. PCT/US1998/013776
International Filing Date 01.07.1998
Chapter 2 Demand Filed 15.01.1999
IPC
C12N 9/60 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14Hydrolases (3.)
48acting on peptide bonds, e.g. thromboplastin, leucine aminopeptidase (3.4)
50Proteinases
58derived from fungi
60from yeast
C12Q 1/37 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
34involving hydrolase
37involving peptidase or proteinase
G01N 33/68 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
CPC
C12N 9/60
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes; Proenzymes; Compositions thereof
14Hydrolases (3)
48acting on peptide bonds (3.4)
50Proteinases ; , e.g. Endopeptidases (3.4.21-3.4.25)
58derived from fungi
60from yeast
C12Q 1/37
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
34involving hydrolase
37involving peptidase or proteinase
G01N 2500/00
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2500Screening for compounds of potential therapeutic value
G01N 33/68
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
Applicants
  • THE UNIVERSITY OF UTAH [US]/[US] (AT, BE, CA, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, JP, KR, LU, MC, NL, PT, SE)
  • EMORY UNIVERSITY [US]/[US] (AT, BE, CA, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, JP, KR, LU, MC, NL, PT, SE)
  • HILL, Christopher, P. [GB]/[US] (UsOnly)
  • WILKINSON, Keith, D. [US]/[US] (UsOnly)
  • JOHNSTON, Steven, C. [US]/[US] (UsOnly)
  • LARSEN, Christopher, N. [US]/[US] (UsOnly)
  • COOK, William, J. [US]/[US] (UsOnly)
Inventors
  • HILL, Christopher, P.
  • WILKINSON, Keith, D.
  • JOHNSTON, Steven, C.
  • LARSEN, Christopher, N.
  • COOK, William, J.
Agents
  • SERTICH, Gary, J.
Priority Data
60/051,43701.07.1997US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHODS AND COMPOSITIONS FOR A DEUBIQUITINATING ENZYME AND VARIANTS THEREOF
(FR) METHODES ET COMPOSITIONS D'OBTENTION D'UNE ENZYME DE DESUBIQUITINATION ET DE SES VARIANTES
Abstract
(EN) The present invention relates to methods for the identification of candidate inhibitor substances that inhibit deubiquitinating activity based on the x-ray crystallographic structure of the active site of the enzyme. Changes in the properties of the enzyme are useful in identifying such substances. Also disclosed are variants of the enzyme that are useful in deubiquitinating proteins and small peptides.
(FR) La présente invention concerne des méthodes d'identification de substances inhibitrices potentielles, inhibant l'activité de desubiquitination, sur la base de la structure cristallographique observée aux rayons X du site actif de l'enzyme. Des modifications des propriétés de l'enzyme sont utiles pour identifier ces substances. L'invention concerne également des variantes de cette enzyme qui sont utiles dans la desubiquitination de protéines et de petites peptides.
Latest bibliographic data on file with the International Bureau