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1. WO1999001431 - NOVEL TRICYCLIC COMPOUNDS HAVING SATURATED RINGS AND MEDICINAL COMPOSITIONS CONTAINING THE SAME

Publication Number WO/1999/001431
Publication Date 14.01.1999
International Application No. PCT/JP1998/002680
International Filing Date 17.06.1998
Chapter 2 Demand Filed 09.07.1998
IPC
C07D 209/88 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
209Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
56Ring systems containing three or more rings
80- or -condensed
82Carbazoles; Hydrogenated carbazoles
88with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
C07D 307/91 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
307Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
77ortho- or peri-condensed with carbocyclic rings or ring systems
91Dibenzofurans; Hydrogenated dibenzofurans
C07D 333/76 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
333Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
50condensed with carbocyclic rings or ring systems
76Dibenzothiophenes
CPC
C07D 209/88
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
209Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
56Ring systems containing three or more rings
80[b, c]- or [b, d]-condensed
82Carbazoles; Hydrogenated carbazoles
88with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
C07D 307/91
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
307Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
77ortho- or peri-condensed with carbocyclic rings or ring systems
91Dibenzofurans; Hydrogenated dibenzofurans
C07D 333/76
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
333Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
50condensed with carbocyclic rings or ring systems
76Dibenzothiophenes
Applicants
  • ASAHI KASEI KOGYO KABUSHIKI KAISHA [JP]/[JP] (AllExceptUS)
  • MIYOSHI, Shiro [JP]/[JP] (UsOnly)
  • OGAWA, Kohei [JP]/[JP] (UsOnly)
Inventors
  • MIYOSHI, Shiro
  • OGAWA, Kohei
Agents
  • KOBAYASHI, Kazunori
Priority Data
9/17819703.07.1997JP
Publication Language Japanese (ja)
Filing Language Japanese (JA)
Designated States
Title
(EN) NOVEL TRICYCLIC COMPOUNDS HAVING SATURATED RINGS AND MEDICINAL COMPOSITIONS CONTAINING THE SAME
(FR) NOUVEAUX COMPOSES TRICYCLIQUES PRESENTANT DES NOYAUX SATURES ET COMPOSITIONS MEDICINALES LES CONTENANT
Abstract
(EN) Compounds represented by general formula (I) or their salts, having $g(b)3-adrenoceptor agonism and being efficacious when employed in drugs for treating and preventing diabetes, obesity, hyperlipemia, etc. wherein R represents hydrogen or methyl; R1 represents hydrogen, halogeno, hydroxy, benzyloxy, amino or hydroxymethyl; R2 represents hydrogen, hydroxymethyl, NHR3, SO2NR4R4', or nitro (wherein R3 represents hydrogen, methyl, SO2R5, formyl or CONHR6'; R5 represents lower alkyl, benzyl or NR4R4'; R4 and R4' may be the same or different and each represents hydrogen, lower alkyl or benzyl; and R6' represents hydrogen or lower alkyl); R6 represents hydrogen or lower alkyl; n is 1 or 2; X represents secondary nitrogen, oxygen or sulfur; and when n is 1, then one of R7 and R8 represents hydrogen while another represents hydrogen, amino, acetylamino or hydroxy, or when n is 2, then R8 represents hydrogen while R7 represents hydrogen, amino, acetylamino or hydroxy.
(FR) L'invention concerne des composés représentés par la formule générale (I), ou leurs sels, qui présentent un effet agoniste vis-à-vis de l'adrénorécepteur $g(b)3 et sont efficaces lorsqu'ils sont employés dans des médicaments pour traiter et prévenir le diabète, l'obésité, l'hyperlipémie, etc. Dans la formule (I), R représente hydrogène ou méthyle; R1 représente hydrogène, halogéno, hydroxy, benzyloxy, amino ou hydroxyméthyle; R2 représente hydrogène, hydroxyméthyle, NHR3, SO2NR4R4' ou nitro (R3 représentant hydrogène, méthyle, SO2R5, formyle ou CONHR6'; R5 représente alkyle inférieur, benzyle ou NR4R4'; R4 et R4' peuvent être identiques ou différents et représentent chacun hydrogène, alkyle inférieur ou benzyle; et R6' représente hydrogène ou alkyle inférieur); R6 représente hydrogène ou alkyle inférieur; n vaut 1 ou 2; X représente azote secondaire, oxygène ou soufre; et quand n vaut 1, l'un des radicaux R7 et R8 représente hydrogène tandis que l'autre représente hydrogène, amino, acétylamino ou hydroxy, ou quand n vaut 2, R8 représente hydrogène, tandis que R7 représente hydrogène, amino, acétylamino ou hydroxy.
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