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1. (WO1998055495) IMMUNOSTIMULATORY OLIGONUCLEOTIDES, COMPOSITIONS THEREOF AND METHODS OF USE THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/055495 International Application No.: PCT/US1998/011578
Publication Date: 10.12.1998 International Filing Date: 05.06.1998
Chapter 2 Demand Filed: 28.12.1998
IPC:
A61K 38/00 (2006.01) ,A61K 39/39 (2006.01) ,C07H 21/00 (2006.01) ,C07K 14/47 (2006.01) ,C12N 15/11 (2006.01) ,C12Q 1/68 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
39
characterised by the immunostimulating additives, e.g. chemical adjuvants
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21
Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
46
from vertebrates
47
from mammals
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants:
DYNAVAX TECHNOLOGIES CORPORATION [US/US]; Suite 500 3099 Science Park Raod San Diego, CA 92121, US (AllExceptUS)
SCHWARTZ, David [US/US]; US (UsOnly)
ROMAN, Mark [US/US]; US (UsOnly)
DINA, Dino [US/US]; US (UsOnly)
RAZ, Eyal [IL/US]; US (UsOnly)
Inventors:
SCHWARTZ, David; US
ROMAN, Mark; US
DINA, Dino; US
RAZ, Eyal; US
Agent:
POLIZZI, Catherine, M.; Morrison & Foerster LLP 755 Page Mill Road Palo Alto, CA 94304-1018, US
Priority Data:
60/048,79306.06.1997US
Title (EN) IMMUNOSTIMULATORY OLIGONUCLEOTIDES, COMPOSITIONS THEREOF AND METHODS OF USE THEREOF
(FR) OLIGONUCLEOTIDES IMMUNOSTIMULATEURS, COMPOSITIONS CORRESPONDANTES ET LEURS PROCEDES D'UTILISATION
Abstract:
(EN) The invention relates to immunostimulatory oligonucleotide compositions. These oligonucleotides comprise an immunostimulatory octanucleotide sequence. These oligonucleotides can be administered in conjunction with an immunostimulatory peptide or antigen. Methods for modulating an immune response upon administration of the oligonucleotide are also disclosed. In addition, an in vitro screening method to identify oligonucleotides with immunostimulatory activity is provided.
(FR) La présente invention se rapporte à des compositions oligonucléotidiques immunostimulatrices. Ces oligonucléotides comportent une séquence octanucléotidique immunostimulatrice. On peut administrer ces oligonucléotides conjointement avec un peptide ou un antigène immunostimulateur. L'invention décrit également des procédés de modulation d'une réaction immunitaire suite à l'administration de l'oligonucléotide concerné, ainsi qu'un procédé de criblage in vitro permettant d'identifier les oligonucléotides à activité immunostimulatrice.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0986572EP1374894JP4101888 JP2002517156 CA2291483AU1998078178