Some content of this application is unavailable at the moment.
If this situation persists, please contact us atFeedback&Contact
1. (WO1998053322) BINDING COMPLEXES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/053322 International Application No.: PCT/GB1998/001485
Publication Date: 26.11.1998 International Filing Date: 22.05.1998
Chapter 2 Demand Filed: 08.12.1998
IPC:
C07H 21/00 (2006.01) ,C07K 14/47 (2006.01) ,C07K 16/18 (2006.01) ,G01N 33/68 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21
Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
46
from vertebrates
47
from mammals
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68
involving proteins, peptides or amino acids
Applicants:
THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL [GB/GB]; Chester Beatty Laboratories 237 Fulham Road London SW3 6JB, GB (AllExceptUS)
WILLISON, Keith [GB/GB]; GB (UsOnly)
HYNES, Gillian [GB/GB]; GB (UsOnly)
LIOU, Anthony, Kian-Fong [SG/US]; US (UsOnly)
Inventors:
WILLISON, Keith; GB
HYNES, Gillian; GB
LIOU, Anthony, Kian-Fong; US
Agent:
KIDDLE, Simon, J. ; Mewburn Ellis York House 23 Kingsway London WC2B 6HP, GB
Priority Data:
9710762.723.05.1997GB
Title (EN) BINDING COMPLEXES
(FR) COMPLEXES DE LIAISON
Abstract:
(EN) The present invention relates to binding members that are capable of binding to and effecting the function of proteins useful in facilitating folding of large polypeptides. The present invention particularly relates to the chaperone CCT. The invention provides materials and methods for effecting the biological activity of CCT within the cell so as to prevent the folding to CCT substrates such as actin, tubulin or cyclin. The inventors provide specific binding members capable of occupying a CCT substrate binding site thereby preventing the substrate from binding. Further, the present invention provides methods for screening for such binding members which effect the biological activity of CCT.
(FR) La présente invention concerne des éléments de liaison susceptibles de se fixer sur des protéines, et de déclencher la fonction de protéines, qui facilite le repliement de grands polypeptides. La présente invention concerne en particulier la chaperone CCT. L'invention a trait à des matières et procédés permettant de déclencher l'activité biologique de la CCT à l'intérieur de la cellule et ce, afin d'empêcher le repliement des chaînes sur les substrats de CCT tels que l'actine, la tubuline ou la cycline. L'invention concerne également des éléments de liaison spécifiques, susceptibles d'occuper un site de fixation du substrat de CCT et donc d'empêcher la fixation du substrat. L'invention concerne enfin des procédés permettant de cribler de tels éléments de liaison qui déclenchent l'activité biologique de la CCT.
Designated States: AU, CA, JP, US
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0983512US7018791CA2294120AU1998075402AU2002038185