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1. (WO1998053319) GENE EXPRESSION PROFILES IN NORMAL AND CANCER CELLS

Pub. No.:    WO/1998/053319    International Application No.:    PCT/US1998/010277
Publication Date: Fri Nov 27 00:59:59 CET 1998 International Filing Date: Thu May 21 01:59:59 CEST 1998
IPC: C12Q 1/68
G01N 33/574
Applicants: THE JOHNS HOPKINS UNIVERSITY
VOGELSTEIN, Bert
KINZLER, Kenneth, W.
Inventors: VOGELSTEIN, Bert
KINZLER, Kenneth, W.
Title: GENE EXPRESSION PROFILES IN NORMAL AND CANCER CELLS
Abstract:
As a step towards understanding the complex differences between normal and cancer cells, gene expression patterns were examined in gastrointestinal tumors. More than 300,000 transcripts derived from at least 45,000 different genes were analyzed. Although extensive similarity was noted between the expression profiles, more than 500 transcripts that were expressed at significantly different levels in normal and neoplastic cells were identified. These data provide insights into the extent of expression differences underlying malignancy and reveal genes that are useful as diagnostic or prognostic markers.