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1. (WO1998053315) IMMUNOASSAYS USING ANTI-ALLOTYPIC MONOCLONAL ANTIBODIES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/053315 International Application No.: PCT/IB1998/000733
Publication Date: 26.11.1998 International Filing Date: 15.05.1998
Chapter 2 Demand Filed: 11.12.1998
IPC:
C07K 16/42 (2006.01) ,G01N 33/53 (2006.01) ,G01N 33/543 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
42
against immunoglobulins (anti-idiotypic antibodies)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
543
with an insoluble carrier for immobilising immunochemicals
Applicants:
BAYER CORPORATION [US/US]; 333 Coney Street East Walpole, MA 02032, US (AllExceptUS)
BARLOW, Eve, H. [US/US]; US (UsOnly)
Inventors:
BARLOW, Eve, H.; US
Agent:
ROESLER, Judith, A.; Bayer Corporation 63 North Street Medfield, MA 02052 , US
Priority Data:
60/046,96219.05.1997US
Title (EN) IMMUNOASSAYS USING ANTI-ALLOTYPIC MONOCLONAL ANTIBODIES
(FR) IMMUNODOSAGES UTILISANT DES ANTICORPS MONOCLONAUX ANTI-ALLOTYPIQUES
Abstract:
(EN) The invention provides improved immunoassay techniques for detecting the presence of analytes in a liquid sample. The present immunoassay methods utilize anti-allotypic monoclonal antibodies as capture reagents for primary binding proteins specific for the analytes of interest. The monoclonal antibodies are highly specific for the allotypic determinants present on the primary binding protein. The use of anti-allotypic monoclonal antibodies as capture reagents provides improved levels of specificity and accuracy of the immunoassay, in part because interference from endogenous immunoglobulins in the sample is significantly reduced. The invention further provides anti-allotypic monoclonal antibodies.
(FR) Cette invention se rapporte à des techniques d'immunodosage améliorées servant à détecter la présence d'analytes dans un échantillon liquide. De tels procédés d'immunodosage utilisent des anticorps monoclonaux anti-allotypiques comme réactifs de capture pour des protéines de liaison primaires spécifiques des analytes d'intérêt. Ces anticorps monclonaux sont hautement spécifiques pour les déterminants allotypiques présents sur les protéines de liaison primaires. L'utilisation d'anticorps monoclonaux anti-allotypiques comme réactifs de capture permet d'obtenir des niveaux accrus de spécificité et de précision de l'immunodosage, en partie parce que l'interférence provenant des immunoglobulines endogènes dans l'échantillon est considérablement réduite. Cette invention se rapporte en outre à des anticorps monoclonaux anti-allotypiques.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
JP2002504994 AU1998070729