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1. (WO1998053300) SYSTEM AND APPARAUS FOR SEQUENTIAL PROCESSING OF ANALYTES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/053300 International Application No.: PCT/US1998/011224
Publication Date: 26.11.1998 International Filing Date: 22.05.1998
Chapter 2 Demand Filed: 14.12.1998
IPC:
B01J 19/00 (2006.01) ,B01L 3/00 (2006.01) ,C12Q 1/68 (2006.01) ,G01N 15/00 (2006.01) ,G01N 15/14 (2006.01) ,G01N 21/25 (2006.01)
B PERFORMING OPERATIONS; TRANSPORTING
01
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
J
CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS, COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
19
Chemical, physical, or physico-chemical processes in general; Their relevant apparatus
B PERFORMING OPERATIONS; TRANSPORTING
01
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
L
CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3
Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
15
Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
15
Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
10
Investigating individual particles
14
Electro-optical investigation
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21
Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible, or ultra-violet light
17
Systems in which incident light is modified in accordance with the properties of the material investigated
25
Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
Applicants:
LYNX THERAPEUTICS, INC. [US/US]; 25861 Industrial Blvd. Hayward, CA 94545, US (AllExceptUS)
PALLAS, Michael, C. [US/US]; US (UsOnly)
BRENNER, Sydney [GB/GB]; GB (UsOnly)
BRIDGHAM, John [US/US]; US (UsOnly)
CORCORAN, Kevin [US/US]; US (UsOnly)
GOLDA, George [US/US]; US (UsOnly)
Inventors:
PALLAS, Michael, C.; US
BRENNER, Sydney; GB
BRIDGHAM, John; US
CORCORAN, Kevin; US
GOLDA, George; US
Agent:
POWERS, Vincent, M. ; Dehlinger & Associates P.O. Box 60850 Palo Alto, CA 94306-0850, US
Priority Data:
08/862,61023.05.1997US
Title (EN) SYSTEM AND APPARAUS FOR SEQUENTIAL PROCESSING OF ANALYTES
(FR) SYSTEME ET APPAREIL DESTINES AU TRAITEMENT SEQUENTIEL DES ANALYTES
Abstract:
(EN) An apparatus and system are provided for simultaneously analyzing a plurality of analytes anchored to microparticles. Microparticles each having a uniform population of a single kind of analyte attached are disposed as a substantially immobilized planar array inside of a flow chamber where steps of an analytical process are carried out by delivering a sequence of processing reagents to the microparticles by a fluidic system under microprocessor control. In response to such process steps, an optical signal is generated at the surface of each microparticle which is characteristic of the interaction between the analyte carried by the microparticle and the delivered processing reagent. The plurality of analytes are simultaneously analyzed by collecting and recording images of the optical signals generated by all the microparticles in the planar array. A key feature of the invention is the correlation of the sequence of optical signals generated by each microparticle in the planar array during the analytical process.
(FR) La présente invention concerne un appareil et un système permettant d'analyser simultanément plusieurs analytes fixés dans des microparticules. Des microparticules possédant chacune une population uniforme composée d'un seul type d'analyte fixé dans celles-ci sont disposées de façon qu'elles forment un réseau plan sensiblement immobilisé à l'intérieur d'une chambre d'écoulement dans laquelle on procède aux différentes phases d'un processus d'analyse en distribuant aux microparticules une série de réactifs de traitement à l'aide d'un système fluidique commandé par un microprocesseur. En réponse aux phases de ce processus, un signal optique est généré à la surface de chaque microparticule, signal qui est caractéristique de l'interaction entre l'analyte porté par la microparticule et le réactif de traitement distribué. On analyse les différents analytes simultanément en collectant et en enregistrant des images des signaux optiques générés par toutes les microparticules du réseau plan. L'invention est caractérisée par la corrélation de la séquence des signaux optiques générés par chaque microparticule du réseau plan au cours du processus d'analyse.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0985142US6406848US20020137052US20030224419US6969488US20060051876
JP2002507280 CA2291180AU1998077155AU2001083651